Side Effects

Question 1

Tamoxifen

Answer 1

Common: arthralgia, alopecia, hot flushes, nausea

Serious: osteoporosis (assess BMD and offer biphosphonates)

Question 2

Exemestane

Answer 2

Common: arthralgia, alopecia, hot flushes, nausea

Serious: Liver disorders, Acute generalized exanthematous postulosis (severe cutaneous adverse reaction)

Question 3

Goserelin

Answer 3

Common: arthralgia, bone pain, gynaecomastia, heart failure, hot flushes, hyperhidrosis, sexual dysfunction, altered mood

Serious: tumour flare, psychotic disorder, pituitary haemorrhage

Question 4

Trastuzumab

Answer 4

Common: angioedema, infusion related symptoms, flu like symptoms, nausea

Serious: Severe infusion related reaction, thrombocytopaenia, heart failure (monitor LVEF)

Question 5

Imatinib

Answer 5

Common: nausea and vomiting, facial oedema, mild fever, diarrhoea, skin rash, muscle cramps and bone pain

Serious: Pancytopaenia, liver toxicity, thromboembolic events, Hep B reactivation

Question 6

Rituximab

Answer 6

Common: angioedema, bone marrow disorders

Serious: infusion related symptoms, cytokine release syndrome, haemolytic anaemia, progressive multifocal encephalopathy, Hep B reactivation

Question 7

Capecitabine

Answer 7

Common: pancytopaenia, diarrhoea, palmar plantar syndrome, fatigue

Serious: severe diarrhoea, acute coronary syndrome, QT prolongation, severe cutaneous adverse reaction