Drug MOA

Question 1

Tamoxifen

Answer 1

Selective Oestrogen Receptor Modulator

Question 2

Selective Oestrogen Receptor Modulator

Answer 2

Tamoxifen
Pro drug metabolized by liver
Prevents binding of oestrogen in target receptors

Question 3

Letrozole

Answer 3

Non-steroidal selective aromatase inhibitor

Question 4

Non-steroidal selective aromatase inhibitor

Answer 4

Letrozole
Inhibits activity of aromatase by binding to its CYP450
Reduces circulating levels of oestrogen

Question 5

Exemestane

Answer 5

Steroidal aromatase inhibitor

Question 6

Steroidal aromatase inhibitor

Answer 6

Exemestane

Reduces synthesis of oestrogen

Question 7

Goserelin

Answer 7

Synthetic analogue of LHRH
Given SC to abdominal wall
Reduced Gn release–> reduced androgens and oestrogens

Question 8

LHRH analogue

Answer 8

Goserelin
Initial stimulation phase
Inhibition of HPG axis

Question 9

Trastuzumab

Answer 9

Monoclonal antibody targeting HER2 receptors

Question 10

HER2 mAb

Answer 10

Trastuzumab

Key role in cell proliferation

Question 11

Imatinib

Answer 11

Tyrosine Kinase Inhibitor (Oral)

Question 12

Tyrosine Kinase inhibitor

Answer 12

Imatinib

Inhibits cell proliferation via inhibition of tyrosine kinase network

Question 13

Rituximab

Answer 13

CD20 Ag mAb

Question 14

CD20 Ag mAb

Answer 14

Rituximab
Antigen present on pre-B and mature B-lymphocytes
Mediates B cell lysis

Question 15

Capecitabine

Answer 15

Pro-drug for 5-fluorouracil

Question 16

5-fluouracil pro-drug

Answer 16

Capecitabine
Inhibits thymidylate synthase
Leads to DNA damage