Drug interactions Flashcards
1
Q
Tamoxifen
A
1) Reduced efficacy with CYP2D6 inhibitors (e.g. fluoxetine/ paroxetine/ quinidine)
2) Enhances effect of warfarin
2
Q
Letrozole
A
1) Avoid in renal impairment
3
Q
Exemestane
A
1) Decreased efficacy with: St. John’s Wort, Rifampicin, Phenytoin, Carbamazepine
4
Q
Goserelin
A
1) Undiagnosed vaginal bleeding
2) Prostate cancer patients at risk of MSCC or ureteric obstruction
3) Cautions for diabetes and hypertension
5
Q
Trastuzumab
A
Few reported
6
Q
Imatinib
A
1) Paracetamol
2) Warfarin
3) Simvastatin
7
Q
Rituximab
A
1) Several significant
2) Live vaccines
8
Q
Capecitabine
A
1) Avoid in DPD deficiency
2) Allopurinol
3) Cimetidine
4) Folic acid
5) Metronidazole
