Side Effects

Question 1

Clozapine.

Answer 1

Weight gain, Salivation, AGRANULOCYTOSIS, neutropenia, myocarditis, arrhthmia

Question 2

Typical antipsychotics.

Answer 2

Parkinsonism, akathisia, tardive dyskinesia and acute dystonia e.g. torticollis.
Neuroleptic malignant syndrome.

Question 3

Oestrogen only HRT.

Answer 3

Increased risk endometrial cancer.

Question 4

Combined HRT.

Answer 4

Increased risk of breast cancer.

Question 5

Psychiatric drug associated with torsades de pointes/QT prolongation.

Answer 5

Citalopram (SSRI).

Question 6

What electrolyte abnormality is associated with SSRIs?

Answer 6

Hyponatraemia.

Question 7

What class of psychiatric drug is associated with hypertension?

Answer 7

SNRIs.

Question 8

Atypical antipsychotics.

Answer 8

Metabolic side effects e.g., weight gain, dyslipidaemia, hyperprolactinaemia, sedation

Question 9

Lithium.

Answer 9

Lithium toxicity → hypothyroidism.

Question 10

Tricyclic antidepressants e.g., clomipramine.

Answer 10

Anticholinergic side effects - dry mouth, blurred vision and urinary retention. Antihistaminic side effects - weight gain.

Question 11

SSRI use during third trimester.

Answer 11

Risk of persistent pulmonary hypertension of the newborn.