Shumate - Asthma Flashcards
what is athma
chronic inflammatory lung disease –> restrictive
what are the 3 cardinal symptoms of asthma
- cough 2. dyspnea 3. wheezing
3 identifiable components of the pathogenesis of athma
- eosinophil and lymphocyte infiltration
- increased cells in proinflammatory state
- alterations in noncellular components in airway
list 4 inflammatory mediators involved in asthma
histamine, LKT, kalikrein, platelet activation factor
what are some pitfalls of provocation testing
- false positive: after recent infection
2. false neg: pt tested on medication
what is a positive provocation test for asthma
> 12% increase in FEV1 + 200 mL increase
OR
increase in FVC or FEF25-75
What classifies intermittent severity of asthma
1.
what is the treatment for intermittent asthma
bronchodilator (no anti-inflammatories needed)
what classified persistent severity of asthma
- can be mild, moderate, or severe
- must have bronchodilator and anti-inflammatory treatment
- mild: >2d/wk, minor limitation of activity
- mod: daily symptoms, some limitation
- severe: throughout the day, extremely limited activity
what are the 4 goals of therapy
- freedom from symptoms
- minimal need for beta agonist
- optimize lung fxn
- maintain NDA
what is the general treatment for asthma exacerbation
short acting inhaled beta agonist –> oxygen–>systemic steroid–>magsulfate
what are the different kinds of treatments available for asthma
rapid/long acting beta agonist, steroids, anticholinergics, theophylline, LTN modifiers, omalizumab
what is omalizumab and how does it work
anti-IgE - only works for certain criteria
What is theophylline and how does it work
anti-inflammatory that inhibits PDE 3 and 4
*bronchoprotective and bronchodilator
name 2 types of short acting anticholinergic meds
- ipratropium bromide - nonsystemic
- atropine sulfate - systemic SE
* not typically used for acute exacerbation
