Shock Flashcards
Vital sign & UOP changes in stage I hemorrhagic shock?
None
Vital sign & UOP changes in stage II hemorrhagic shock?
RR elevation 20-30. Pulse > 100. UOP 20-30.
Vital sign & UOP changes in stage III hemorrhagic shock?
RR elevation 30-40. Pulse >120. Hypotensive. UOP 5-15.
Vital sign & UOP changes in stage IV hemorrhagic shock?
RR > 35. Pulse >140. Hyptoensive. UOP negliglible.
Type of shock caused by thyroid storm?
Distributive.
Type of shock caused by Paget’s disease?
Distributive.
Type of shock caused by Thiamine-deficiency?
Distributive.
3 components of qSOFA?
- RR>=22
- AMS
- SBP=<100
Difference between CMS definition vs Sepsis-3 definition of “Septic Shock”?
- Sepsis-3: pressors and LA>2
- CMS: pressors or LA>4
Location and function of alpha-1 receptors?
In vascular smooth muscles. Causes vasoconstriction.
Location and function of alpha-2 receptors?
In CNS, platelets. Causes sedation, analgesia, platelet aggregation.
Location and function of beta-1 receptors?
In heart. Mediates contractility & tachycardia.
Location and function of beta-2 receptors?
Located in smooth muscles of bronchi, mediates bronchodilation. Also located in blood vessels, mediates dilation of coronary and skeletal vasculature.
Dopamine functions at which receptors, based on dose?
Alpha, then beta, then DA.
Location and function of angiotensin receptors?
Located in adrenal zona glomerulosa, vascular smooth muscle, kidney, brain, anterior pituitary. Causes vasoconstriction.
Receptor and effect of phenylephrine?
Alpha-1 only. Causes vasoconstriction.
Receptor and effect of norepinephrine?
3x alpha-1. 2x beta-1. Causes mainly vasoconstriction, and some increased cardiac output.
Receptor and effect of epinephrine?
3x alpha-1, 3x beta-1, 2x-beta-2. Causes increased cardiac output, variable effect on SVR.
Receptor and effect of low-dose dopamine?
Mild beta-1, and D1. Causes increased cardiac output and variable effect on SVR.
Receptor and effect of med-dose dopamine?
1x alpha-1, 2x beta-1, 2x DA. Causes increased cardiac output and SVR.
Receptor and effect of high-dose dopamine?
2x alpha-1, 2x beta-1, 2x DA. Causes increased cardiac output and SVR.
Receptor and effect of dobutamine?
3x beta-1, 2x beta-2. Causes increased cardiac output and lower SVR.
Hemodynamic effect of vasopressin?
Causes increased SVR.
Contraindications to vasopressin infusion?
Cardiac, skin, or intestinal ischemia.
