Sheet2-表格 1 Flashcards
What are 2 disease processes caused by Viridans strep and what species are responsible?
1) dental caries: Strep.mutans
2) bacterial endocarditis: Strep. Sanguis
What are 2 options for triple treatment of H.
pylori?
(1) bismuth (Pepto-Bismal),metronidazole, and tetracyclin or amoxicillin. OR
(2) metronidazole, omeprazole, and clarithromycin (#2 is more expensive)
What are 3 advantages/differences between VDRL and FTA-ABS?
FTA-ABS is
1) more specific
2) positive earlier in disease
3) remains positive longer than VDRL
What are 3 disease processes caused by Strep. pyogenes?
1) Pyogenic–pharyngitis,cellulitis, skin infection
2) Toxigenic–scarlet fever, TSS
3) Immunologic–rheumatic fever, acute
glomerulonephritis
What are 4 biological false positives for VDRL?
1) Viruses (mono, hepatitis)
2) Drugs
3) Rheumatic fever and rheumatic arthritis
4) Lupus and leprosy (=VDRL)
What are 4 clinical symptoms of ‘walking’ pneumonia?
1) insidious onset
2) headache
3) nonproductive cough
4) diffuse interstitial infiltrate
What are 4 clinical symptoms of TB?
1) fever
2) night sweats
3) weight loss
4) hemoptysis
What are 5 areas that can be affected by extrapulmonary TB?
1) CNS (parenchmal tuberculoma or meningitis)
2) Vertebral body (Pott’s disease)
3) Lymphadenitis
4) Renal
5) GI
What are the culture requirement for H. flu?
culture on chocolate agar with factor V (NAD) and X (hematin).
[Think: ‘Child has ‘flu’; mom goes to five (V) and dime (X) store to buy
chocolate.’]
What are the lab findings with Chlamydia?
cytoplasmic inclusions on Giemsa fluorescent antibody stains smear
What are the symptoms of RMSF? (3)
1) rash on palms and soles (migrating to wrists, ankles, then trunck)
2) headache
3) fever
What are the three stages of Lyme disease?
1) erythema chronicum migrans, flu-like symptoms
2) neurologic and cardiac manefestations
3) autoimmune migratory polyarthritis
What are the two forms of chlamydia?
1) Elementary body (small, dense): Enters cell via endocytosis
2) Initial or Reticulate body: Replicates in the cell by fission
What are the two forms of leprosy (or Hansen’s disease)?
1) lepromatous- failed cellmediated immunity, worse
2) tuberculoid- self-limited.
What are two drugs that could be used to treat ‘walking’ pneumonia?
tetracycline or erythromycin
What are two drugs that could treat Chlmydia?
erythromycin or tetracycline
What are two lab findings associated with ‘walking’ pneumonia?
1) X-ray looks worse than patient
2) High titer of cold agglutinins (IgM)
What are usually associated with pseudomembraneous colitis?
Clostridium difficile; it kills enterocytes, usu. is overgrowth secondary to antibiotic use (esp. clindamycin or ampicillin)
What bacteria are G+, sporeforming, anaerobic bacilli?
Clostridia
What bacteria causes a malignant pustule (painless ulcer); black skin lesions that are vesicular papules covered by a blak eschar?
Bacillus anthracis
What bacteria exhibits a ‘tumbling’ motility, is found in unpasteurized milk, and causes meningitis in newborns?
Listeria monocytogenes
What bacteria is catalase(-) and bacitracin-resistant?
Strep. agalactiae
What bacteria is catalase(-) and bacitracin-sensitive?
Strep. pyogenes
What bacteria is catalase+ and coagulase+?
Staph. aureus
What bacteria produces alpha-toxin, a hemolytic lecithinase that causes
myonecrosis or gas gangrene?
Clostridium perfringens
What bacterium causes Cellulitis?
Pasteurella multocida
What bacterium causes leprosy?
Mycobacterium leprae
What bacterium causes Lyme disease?
Borrelia burgdorferi
What bacterium causes the Plague?
Yersinia pestis
What bacterium causes Tularemia?
Francisella tularensis
What bacterium causes Undulant fever?
Brucella spp. (a.k.a. Brucellosis)
What bug causes atypical ‘walking’ pneumonia?
Mycoplama pneumoniae
What bug causes gastroenteritis and up to 90% of duodenal ulcers?
Helicobacter pylori
What bug causes Legionnaire’s disease?
Legionella pneumophila
What bug is associated with burn wound infections?
Pseudomonas aeruginosa
What bug is comma- or Sshaped and grows at 42C, and causes bloody diarrhea with fever and leukocytosis?
Campylobacter jejuni
What bug that causes diarrhea is usually
transmitted from pet feces (e.g. puppies)?
Yersinia enterocolitica
What causes tetanus? (give bacteria and disease process)
Clostridium tetani: exotoxin produced blocks glycine release (inhibitory NT) from Renshaw cells in spinal cord
What causes the flu?
NOT H. flu -it is caused by influenza virus
What chemical is found in the core of spores?
dipicolinic acid
What coccobacillus causes vaginosis: greenish vaginal discharge with a fishy smell;
nonpainful?
Gardnerella vaginalis
What disease does Bordetella perussis cause? How?
Whooping cough: toxin permanently disables G-protein in respiratory mucosa (turns the ‘off’ off); ciliated epithelial cells are killed; mucosal cells are overactive
What disease does Vibrio cholerae cause? How?
Cholera: toxin permanently activates G-protein in intestinal mucosa (turns the ‘on’ on) causing rice-water diarrhea
What disease is caused by Borrelia?
Lyme Disease
What disease is caused by Clostridium botulinum? What pathophys. does it cause?
Botulism: associated with contaminated canned food, produces a preformed, heat labile toxin that inhibits ACh release—> flaccid paralysis.
What diseases (2) are caused by Treponema?
- Syphilis (T. pallidum)
- Yaws (T. pertenue; not and STD)
What diseases can be caused by Staph. aureus?
- Inflammatory disease: skin infections, organ abscess, pneumonia
- Toxinmediated disease: Toxic Shock Syn., scalded skin syndrome (exfoliative toxin), rapid onset food poisoning (enterotoxins)
What do Chlamydia trachomatis serotypes A, B, and C cause?
chronic infection, cause blindness in Africa (ABC= Africa / Blindness / Chronic
What do Chlamydia trachomatis serotypes D-K cause? (3)
- urethritis/ PID
- neonatal pneumonia
- neonatal conjuctivitis
What do Chlamydia trachomatis serotypes L1,L2, and L3 cause?
lymphogranuloma venereum (acute lymphadentis: positive Frei test)
What do RMSF, syphilis, and coxsackievirus A infection have in common?
rash on palm and sole is seen in each (coxasackievirus A =hand, foot, and mouth disease)
What does catalase do? Which bacteria have it?
It degrades H2O2, an antimicrobial product of
PMNs.
- Staphlococci make catalase; Strep. do NOT.
What does the H-antigen represent?
H: flagellar antigen, found on motile specie
What does the K-antigen represent?
K: capsular, relates to virulence
What does the O-antigen represent?
O-antigen is the polysaccharide of endotoxin (found on all species)
What does VDRL detect? (It detects non-specific antibody that reacts with what?)
detects antibody that reacts with beef cardiolipin
What drug of choice is used to treat Norcardia? Actinomyces? (Acronym: SNAP)
Sulfa for Norcarida, Actinomyces gets Penicillin
What enteric bacterial infection may be prolonged with antibiotic treatment?
Salmonellosis
What enzyme allows H. pylori to create an alkaline environment?
urease (cleaves urea to ammonia); used in urease breath test
What family includes E. coli, Salmonella, Klebsiella, Enterobacter, Serratia, and
Proteus?
Enterobacteriaceae
What family of bacteria uses the O-, K-, and H-antigen nomenclature?
Enterobacteriaceae
What function does the capsule serve? (2: one for the bacterium, one other)
1) antiphagocytic
2) antigen in vaccines (Pneumovax, H. flu B, meningococcal vaccines)
What G+ anaerobe causes oral/facial abscesses with ‘sulfur granules’ that may
drain through sinus tracts in skin?
Acinomyces israelii
What G+ and also weakly acid fast aorobe found in soil causes pulmonary infections
in immunocompromised patients?
Norcardia asteroides
What general type of bacteria are normal flora in GI tract but pathogenic elsewhere?
Anaerobes
What general type of bacteria grow pink colonies on MacConkey’s agar?
Lactose-fermenting enteric bacteria
What is a Ghon complex and in whom does it occur?
- Occurs in Primary TB (usually a child)
- Ghon complex= draining Hilar nodes and Ghon focus, exudative parenchymal lesion (usu. in LOWER lobes of lung)
What is a lab diagnosis of diphtheria based on?
G+ rods with metachromatic granules; grows on tellurite agar. (Coryne=club shaped)
What is a major difference between Salmonella and Shigella observable in the lab?
- Salmonella are motile;
- Shigella are nonmotile
What is a positive Quellung reaction?
if encapsulated bug is present, capsule SWELLS when specific anticapsular antisera are added.
What is notable about Chrmydia psittaci?
has an avian reservoir
What is one reason M. leparae infects skin and superficial nerves?
It likes cool temperatures
What is the classic symptom of Lyme Disease?
erythema chronicum migrans, an expanding ‘bull’s eye’ red rash with central clearing.
What is the classic triad of symptoms associated with Rickettsiae?
1) headache
2) fever
3) rash (vasiculitis)
What is the common manifestation of secondary TB?
Fibrocaseous cavitary lesion usu. in APICIES of lung
What is the common site of infection for Mycobacterium tuberculosis?
the apicies of the lung (which have the highest PO2)
What is the D.O.C. to treat Gardnerella vaginalis?
Metroidazole
What is the DOC for treating rickettsial infections?
tetracycline
What is the DOC for treatment of most rickettsial infections?
tetracycline