SH Drugs

Question 1

Ipilimumab

Answer 1

monoclonal antibody, anti-CTLA4 (cancer)

Question 2

Nivolumab

Answer 2

monoclonal antibody, anti-PD1 (cancer)

Question 3

Adalimumab

Answer 3

monoclonal antibody, anti-TNF (RA, inflam)

Question 4

Palivisumab

Answer 4

monoclonal antibody against respiratory syncytical virus

Question 5

Zanamivir

Answer 5

inhibit viral neuraminidase (FluA & B, release inhibitor). Effective w/in 30 hrs of Sx, shorten illness 1.5-2.5 days.

Question 6

Oseltamivir

Answer 6

inhibit viral neuraminidase (FluA & B, release inhibitor). Effective w/in 30 hrs of Sx, shorten illness 1.5-2.5 days.

Question 7

Maravirox

Answer 7

HIV entry inhibitor, block CCR5

Question 8

Enfuvirtide

Answer 8

HIV entry inhibitor, bind & block gp41

Question 9

Raltegravir

Answer 9

HIV Integrase inhibitor, inhibit strand transfer

Question 10

Aciclovir

Answer 10

NRTI

Question 11

Zidovudine

Answer 11

NRTI

Question 12

Stavudine

Answer 12

NRTI

Question 13

Lamivudine

Answer 13

NRTI

Question 14

Abacavir

Answer 14

NRTI

Question 15

Tenofovir

Answer 15

Antiviral, nucleotide analogue

Question 16

Nevirapine

Answer 16

NNRTI

Question 17

Efavirenz

Answer 17

NNRTI

Question 18

Indinavir Sulfate

Answer 18

HIV protease inhibitor

Question 19

Saquinavir

Answer 19

HIV protease inhibitor

Question 20

Amantadines

Answer 20

block influenza M2 protein (proton channel). No longer recommended, resistant.

Question 21

Isoniazid

Answer 21

Inhibit cell wall constituent synth in mycobacteria. TB 1st line

Question 22

Rifampicin

Answer 22

inhibit DNA dependent RNA polymerase, supress chain formation RNA synth. TB first line

Question 23

Ethambutol

Answer 23

inhibit cell wall synth by blocking arabinosyl transferase. TB first line

Question 24

Pyrazinamide

Answer 24

Affects fatty acid synthase, cellw all synth. Kills bacteria when acidic, effective against bacteria inside macrophage. TB first line

Question 25

Streptomycin

Answer 25

inhibit protein synth (binds ribosome). TB 2nd line

Question 26

Capreomycin

Answer 26

interferes ribosome function. TB 2nd line

Question 27

Bedaquiline

Answer 27

New TB drug. Inhibit proton pump of ATP synthase. high risk.

Question 28

Nitromidazole

Answer 28

inhibit mycolic acid production. eg. pretomanic.

Question 29

Salbutamol

Answer 29

SABA, asthma

Question 30

Terbutaline

Answer 30

SABA, asthma

Question 31

Salmeterol

Answer 31

LABA, asthma

Question 32

Eformoterol

Answer 32

LABA, asthma

Question 33

Theophylline

Answer 33

Inhib phosphodiesterase, increase IC cAMP, inhib inflam cell activ. asthma.

Question 34

Ipratropium

Answer 34

Muscarinic rcpt antagonist, asthma

Question 35

Beclomethasone

Answer 35

glucocorticoid, asthma

Question 36

Beudesonide

Answer 36

glucocorticoid, asthma

Question 37

Fluticasone

Answer 37

glucocorticoid, asthma

Question 38

Symbicort

Answer 38

combination, eformoterol + beudesonide, asthma

Question 39

Seretide

Answer 39

Combination, salmeterol + flluticasone, asthma

Question 40

Montelukast

Answer 40

Leukotriene rcpt antagonist, asthma

Question 41

Zafirlukast

Answer 41

Leukotriene rcpt antagonist, asthma

Question 42

Zileutin

Answer 42

Leukotriene synth inhibitor, asthma

Question 43

Sodium cromoglycate

Answer 43

prevent MC degranulation, asthma

Question 44

Nedocromil sodium

Answer 44

prevent MC degranulation, asthma

Question 45

Omalizumab

Answer 45

monoclonal antiB against IgE, new drug for asthma

Question 46

Cycloserine

Answer 46

Mimic alanine, inhibit cell wall synthesis, penetrate CNS.