SH Drugs Flashcards

1
Q

Ipilimumab

A

monoclonal antibody, anti-CTLA4 (cancer)

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2
Q

Nivolumab

A

monoclonal antibody, anti-PD1 (cancer)

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3
Q

Adalimumab

A

monoclonal antibody, anti-TNF (RA, inflam)

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4
Q

Palivisumab

A

monoclonal antibody against respiratory syncytical virus

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5
Q

Zanamivir

A

inhibit viral neuraminidase (FluA & B, release inhibitor). Effective w/in 30 hrs of Sx, shorten illness 1.5-2.5 days.

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6
Q

Oseltamivir

A

inhibit viral neuraminidase (FluA & B, release inhibitor). Effective w/in 30 hrs of Sx, shorten illness 1.5-2.5 days.

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7
Q

Maravirox

A

HIV entry inhibitor, block CCR5

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8
Q

Enfuvirtide

A

HIV entry inhibitor, bind & block gp41

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9
Q

Raltegravir

A

HIV Integrase inhibitor, inhibit strand transfer

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10
Q

Aciclovir

A

NRTI

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11
Q

Zidovudine

A

NRTI

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12
Q

Stavudine

A

NRTI

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13
Q

Lamivudine

A

NRTI

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14
Q

Abacavir

A

NRTI

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15
Q

Tenofovir

A

Antiviral, nucleotide analogue

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16
Q

Nevirapine

A

NNRTI

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17
Q

Efavirenz

A

NNRTI

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18
Q

Indinavir Sulfate

A

HIV protease inhibitor

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19
Q

Saquinavir

A

HIV protease inhibitor

20
Q

Amantadines

A

block influenza M2 protein (proton channel). No longer recommended, resistant.

21
Q

Isoniazid

A

Inhibit cell wall constituent synth in mycobacteria. TB 1st line

22
Q

Rifampicin

A

inhibit DNA dependent RNA polymerase, supress chain formation RNA synth. TB first line

23
Q

Ethambutol

A

inhibit cell wall synth by blocking arabinosyl transferase. TB first line

24
Q

Pyrazinamide

A

Affects fatty acid synthase, cellw all synth. Kills bacteria when acidic, effective against bacteria inside macrophage. TB first line

25
Q

Streptomycin

A

inhibit protein synth (binds ribosome). TB 2nd line

26
Q

Capreomycin

A

interferes ribosome function. TB 2nd line

27
Q

Bedaquiline

A

New TB drug. Inhibit proton pump of ATP synthase. high risk.

28
Q

Nitromidazole

A

inhibit mycolic acid production. eg. pretomanic.

29
Q

Salbutamol

A

SABA, asthma

30
Q

Terbutaline

A

SABA, asthma

31
Q

Salmeterol

A

LABA, asthma

32
Q

Eformoterol

A

LABA, asthma

33
Q

Theophylline

A

Inhib phosphodiesterase, increase IC cAMP, inhib inflam cell activ. asthma.

34
Q

Ipratropium

A

Muscarinic rcpt antagonist, asthma

35
Q

Beclomethasone

A

glucocorticoid, asthma

36
Q

Beudesonide

A

glucocorticoid, asthma

37
Q

Fluticasone

A

glucocorticoid, asthma

38
Q

Symbicort

A

combination, eformoterol + beudesonide, asthma

39
Q

Seretide

A

Combination, salmeterol + flluticasone, asthma

40
Q

Montelukast

A

Leukotriene rcpt antagonist, asthma

41
Q

Zafirlukast

A

Leukotriene rcpt antagonist, asthma

42
Q

Zileutin

A

Leukotriene synth inhibitor, asthma

43
Q

Sodium cromoglycate

A

prevent MC degranulation, asthma

44
Q

Nedocromil sodium

A

prevent MC degranulation, asthma

45
Q

Omalizumab

A

monoclonal antiB against IgE, new drug for asthma

46
Q

Cycloserine

A

Mimic alanine, inhibit cell wall synthesis, penetrate CNS.