HMA Drugs

Question 1

Chlorothiazide

Answer 1

Thiazide diuretic

Question 2

Propranolol

Answer 2

Non-selective beta AR antag

Question 3

Pindolol

Answer 3

Non-selective beta AR antag

Question 4

Atenolol

Answer 4

B1 selective AR antag

Question 5

Metoprolol

Answer 5

B1 selective AR antag

Question 6

Prazosin

Answer 6

A1 seletive AR antag

Question 7

Nifedipine

Answer 7

Dihydropyridines, L type VOCC Antag

Question 8

Verapamil

Answer 8

Ca Channel Blocker

Question 9

Enalalpril

Answer 9

ACEI

Question 10

Losartan

Answer 10

ARB

Question 11

Aliskirin

Answer 11

Renin inhib

Question 12

Class: Thiazide

[MoA, AE]

Answer 12

MoA: Inhib Na/Cl cotransporter, decrease water reabs, decrease BV

AE: hyponatraemia, hypokalaemia, diabetes

Question 13

Class: beta antag

[MoA, AE]

Answer 13

MoA: inhib beta AR, decrease HR contractility, kidney renin, CO & TPR

AE: bronchospasm, cold hands/feet, increase TG, fatigue.

Question 14

Class: alpha antag

[MoA, AE]

Answer 14

MoA: Block alpha AR, dilate A & V

AE: Postural hypotention, weak, drowsy

Question 15

Class: Ca channel blocker

[MoA, AE]

Answer 15

MoA: Block L type VOCC, relax art smooth M, vasodilate.

AE: Oedema, flushing, headache

Question 16

Class: ACEI

[MoA, AE]

Answer 16

MoA: Block ACE, no AngII, vasodilate & aldosterone

AE: hypotension, renal failure, hyperkalaemia, cough, rash.

Question 17

Class: ARB

[MoA, AE]

Answer 17

MoA: Block AT1

AE: hyperkalaemia, headache, dizzy, no cough

Question 18

Class: Renin inhibitor

[MoA, AE]

Answer 18

MoA: inhib renin, decrease AngII & Aldo

AE: renal fail, hypotention, hyperkalaemia, dizzy

Question 19

Class: Loop Diuretic

[MoA, AE]

Answer 19

MoA: Inhib Na/2Cl/K cotransporter in thick ascending LoH. Inhib water reabs, decrease BV

AE: hypokalaemia, hypovolaemia, hyponatraemia.

Question 20

Frusemide

Answer 20

Loop diuretic

Question 21

Class: K-Sparing Diuretic

[MoA, AE]

Answer 21

MoA: Aldosterone antag. may reverse CF remodelling & fibrosis.

AE: No hypokalaemia

Question 22

Spironolatone

Answer 22

K-Sparing Diuretic

Question 23

Perindopril

Answer 23

ACEI

Question 24

Cadesartan

Answer 24

ARB

Question 25

Class: Nitrates | [MoA, AE]

Answer 25

MoA: Affect Ca in vessel smooth m through cGMP & PKG. AE: flushing, headache, hypotension, reflex tachycardia

Question 26

Glycerol trinitrate

Answer 26

Nitrate

Question 27

Isosorbide dinitrate

Answer 27

Nitrate

Question 28

Class: Hydrallazine | [MoA, AE]

Answer 28

MoA: Vasodilator, unknown mech AE: hypotension, tachycardia, headache.

Question 29

Carvedilol

Answer 29

Non selective beta blocker for CF

Question 30

Class: Cardiac glycoside | [MoA, AE]

Answer 30

MoA: Inhib Na/K ATPase, decrease Ca efflux, increase IC [Ca} increase contractility AE: Anorexia, diarrhoea, drowsy, confuse, psychosis, vent arrhythmia

Question 31

Digoxin

Answer 31

Cardiac glycoside

Question 32

Class: Phosphodiesterase inhibitors | [MoA, AE]

Answer 32

MoA: prevent cAMP breakdown, increase contractility AE: GIT, hepatotoxicity, vent arrhythmia

Question 33

Milrinone

Answer 33

Phosphodiesterase inhibitor

Question 34

Class: beta agonist | [MoA, AE]

Answer 34

MoA: stim beta 1 rcpt, increase contractility, increase renal perfusion. AE: arrhythmia, downreg rcpt, symp overstimulation

Question 35

Dobutamine

Answer 35

beta agonist

Question 36

Class: Statins | [MoA, AE]

Answer 36

MoA: Inhib HMG-CoA, inhib cholesterol synthesis. AE: Mild. CI liver disease.

Question 37

Atorvastatin

Answer 37

Statin

Question 38

Rosuvastatin

Answer 38

Statin

Question 39

Class: Fibrates | [MoA, AE]

Answer 39

MoA: Bind PPAR-alpha, enter nucleis, decrease transcription of lipolysis enzymes, decrease plasma FA, increase reverse transport. AE: GIT, CI renal/gallbladder failure

Question 40

Fenofibrate

Answer 40

Fibrate

Question 41

Femifibrozil

Answer 41

Fibrate

Question 42

Class: Bile acid sequestrants | [MoA, AE]

Answer 42

MoA: Inhib biliary chol reabs. AE: Rash, CI biliary obstruction.

Question 43

Cholestyramine

Answer 43

Bile acid sequestrant

Question 44

Colestipol

Answer 44

Bile acid sequestrant

Question 45

Class: Nicotinic Acid | [MoA, AE]

Answer 45

MoA: bind GPR109A on adipose, inhib lipolysis, decrease blood FA, increase HDL AE: GIT, CI liver disease, gout, peptic ulcer.

Question 46

Niacin

Answer 46

Nicotinic acid

Question 47

Acipimox

Answer 47

Nicotinic acid

Question 48

Class: Benzodiazepine | [MoA, AE]

Answer 48

MoA: Bind GABA-A rcpt, increase GABA affinity, increase inhibitory action of GABA AE: fatigue, dizzy, confusion, amnesia, ataxia, falls

Question 49

Diazepam

Answer 49

Benzodiazepine

Question 50

Class: SSRI | [MoA, AE]

Answer 50

MoA: Block SERT, inhib serotonin reuptake AE: nausea, insomnia, wt change

Question 51

Thiopental

Answer 51

IV general anaesthetic

Question 52

Propofol

Answer 52

IV General anaesthetic

Question 53

Ketamine

Answer 53

IV general anaesthetic

Question 54

Nitrious oxide

Answer 54

inhalation general anaesthetic

Question 55

Isoflurane

Answer 55

inhalation general anaesthetic

Question 56

Enflurane

Answer 56

inhalation general anaesthetic

Question 57

Desflurane

Answer 57

inhalation general anaesthetic

Question 58

Sevoflurane

Answer 58

inhalation general anaesthetic

Question 59

Lignocaine

Answer 59

Local anaesthetic

Question 60

Tetracaine

Answer 60

Local anaesthetic

Question 61

Debucaine

Answer 61

Local anaesthetic

Question 62

Prilocaine

Answer 62

Local anaesthetic

Question 63

Bupivacaine

Answer 63

Local anaesthetic