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Pharmacology > HMA Drugs > Flashcards

HMA Drugs Flashcards

1
Q

Chlorothiazide

A

Thiazide diuretic

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2
Q

Propranolol

A

Non-selective beta AR antag

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3
Q

Pindolol

A

Non-selective beta AR antag

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4
Q

Atenolol

A

B1 selective AR antag

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5
Q

Metoprolol

A

B1 selective AR antag

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6
Q

Prazosin

A

A1 seletive AR antag

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7
Q

Nifedipine

A

Dihydropyridines, L type VOCC Antag

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8
Q

Verapamil

A

Ca Channel Blocker

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9
Q

Enalalpril

A

ACEI

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10
Q

Losartan

A

ARB

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11
Q

Aliskirin

A

Renin inhib

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12
Q

Class: Thiazide

[MoA, AE]

A

MoA: Inhib Na/Cl cotransporter, decrease water reabs, decrease BV

AE: hyponatraemia, hypokalaemia, diabetes

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13
Q

Class: beta antag

[MoA, AE]

A

MoA: inhib beta AR, decrease HR contractility, kidney renin, CO & TPR

AE: bronchospasm, cold hands/feet, increase TG, fatigue.

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14
Q

Class: alpha antag

[MoA, AE]

A

MoA: Block alpha AR, dilate A & V

AE: Postural hypotention, weak, drowsy

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15
Q

Class: Ca channel blocker

[MoA, AE]

A

MoA: Block L type VOCC, relax art smooth M, vasodilate.

AE: Oedema, flushing, headache

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16
Q

Class: ACEI

[MoA, AE]

A

MoA: Block ACE, no AngII, vasodilate & aldosterone

AE: hypotension, renal failure, hyperkalaemia, cough, rash.

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17
Q

Class: ARB

[MoA, AE]

A

MoA: Block AT1

AE: hyperkalaemia, headache, dizzy, no cough

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18
Q

Class: Renin inhibitor

[MoA, AE]

A

MoA: inhib renin, decrease AngII & Aldo

AE: renal fail, hypotention, hyperkalaemia, dizzy

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19
Q

Class: Loop Diuretic

[MoA, AE]

A

MoA: Inhib Na/2Cl/K cotransporter in thick ascending LoH. Inhib water reabs, decrease BV

AE: hypokalaemia, hypovolaemia, hyponatraemia.

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20
Q

Frusemide

A

Loop diuretic

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21
Q

Class: K-Sparing Diuretic

[MoA, AE]

A

MoA: Aldosterone antag. may reverse CF remodelling & fibrosis.

AE: No hypokalaemia

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22
Q

Spironolatone

A

K-Sparing Diuretic

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23
Q

Perindopril

A

ACEI

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24
Q

Cadesartan

A

ARB

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25
Q

Class: Nitrates

[MoA, AE]

A

MoA: Affect Ca in vessel smooth m through cGMP & PKG.

AE: flushing, headache, hypotension, reflex tachycardia

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26
Q

Glycerol trinitrate

A

Nitrate

27
Q

Isosorbide dinitrate

A

Nitrate

28
Q

Class: Hydrallazine

[MoA, AE]

A

MoA: Vasodilator, unknown mech

AE: hypotension, tachycardia, headache.

29
Q

Carvedilol

A

Non selective beta blocker for CF

30
Q

Class: Cardiac glycoside

[MoA, AE]

A

MoA: Inhib Na/K ATPase, decrease Ca efflux, increase IC [Ca} increase contractility

AE: Anorexia, diarrhoea, drowsy, confuse, psychosis, vent arrhythmia

31
Q

Digoxin

A

Cardiac glycoside

32
Q

Class: Phosphodiesterase inhibitors

[MoA, AE]

A

MoA: prevent cAMP breakdown, increase contractility

AE: GIT, hepatotoxicity, vent arrhythmia

33
Q

Milrinone

A

Phosphodiesterase inhibitor

34
Q

Class: beta agonist

[MoA, AE]

A

MoA: stim beta 1 rcpt, increase contractility, increase renal perfusion.

AE: arrhythmia, downreg rcpt, symp overstimulation

35
Q

Dobutamine

A

beta agonist

36
Q

Class: Statins

[MoA, AE]

A

MoA: Inhib HMG-CoA, inhib cholesterol synthesis.

AE: Mild. CI liver disease.

37
Q

Atorvastatin

A

Statin

38
Q

Rosuvastatin

A

Statin

39
Q

Class: Fibrates

[MoA, AE]

A

MoA: Bind PPAR-alpha, enter nucleis, decrease transcription of lipolysis enzymes, decrease plasma FA, increase reverse transport.

AE: GIT, CI renal/gallbladder failure

40
Q

Fenofibrate

A

Fibrate

41
Q

Femifibrozil

A

Fibrate

42
Q

Class: Bile acid sequestrants

[MoA, AE]

A

MoA: Inhib biliary chol reabs.

AE: Rash, CI biliary obstruction.

43
Q

Cholestyramine

A

Bile acid sequestrant

44
Q

Colestipol

A

Bile acid sequestrant

45
Q

Class: Nicotinic Acid

[MoA, AE]

A

MoA: bind GPR109A on adipose, inhib lipolysis, decrease blood FA, increase HDL

AE: GIT, CI liver disease, gout, peptic ulcer.

46
Q

Niacin

A

Nicotinic acid

47
Q

Acipimox

A

Nicotinic acid

48
Q

Class: Benzodiazepine

[MoA, AE]

A

MoA: Bind GABA-A rcpt, increase GABA affinity, increase inhibitory action of GABA

AE: fatigue, dizzy, confusion, amnesia, ataxia, falls

49
Q

Diazepam

A

Benzodiazepine

50
Q

Class: SSRI

[MoA, AE]

A

MoA: Block SERT, inhib serotonin reuptake

AE: nausea, insomnia, wt change

51
Q

Thiopental

A

IV general anaesthetic

52
Q

Propofol

A

IV General anaesthetic

53
Q

Ketamine

A

IV general anaesthetic

54
Q

Nitrious oxide

A

inhalation general anaesthetic

55
Q

Isoflurane

A

inhalation general anaesthetic

56
Q

Enflurane

A

inhalation general anaesthetic

57
Q

Desflurane

A

inhalation general anaesthetic

58
Q

Sevoflurane

A

inhalation general anaesthetic

59
Q

Lignocaine

A

Local anaesthetic

60
Q

Tetracaine

A

Local anaesthetic

61
Q

Debucaine

A

Local anaesthetic

62
Q

Prilocaine

A

Local anaesthetic

63
Q

Bupivacaine

A

Local anaesthetic

Pharmacology (4 decks)

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