SGLT2 inhibitors Flashcards
1
Q
where are SGLT2 proteins expressed
A
PROXIMAL renal tubule**
note: is responsible for the reabsorption of filtered glucose, by inhibiting SGLT2 these drugs REDUCE REABSORPTION* of glucose and INCREASE URINARY EXCRETION*, which decreases BG
2
Q
most guidelines now recommend SGLT2i use if eGFR is ≥ ?
A
recommend use if eGFR ≥ 20 ml/min/1.73^3
3
Q
SGLT2i drug interactions
A
increased risk of intravascular volume depletion (causing HYPOTENSION* and AKI) if used in combination with DIURETICS, RAAS inhibitors, NSAIDs**
4
Q
list SGLT2i drugs
A
*Canagliflozin (Invokana)
*Dapagliflozin (Farxiga)
*Empagliflozin (Jardiance)
Ertugliflozin (Steglatro)
5
Q
SGLT2i can cause (warnings)
A
- Ketoacidosis* (stop prior to surgery to reduce risk)
- hypOtension* and AKI (due to intravascular VOLUME DEPLETION*)
- severe UTIs and genital fungal infections* (genital mycotic infections, UROSEPSIS and PYELONEPHRITIS, necrotizing fascitis/perineum)
- canagliflozin and bexagliflozin: increased risk of amputation (avoid if foot problems, neuropathy), risk of FRACTURES*
6
Q
side effects SGLT2i
A
- increased urination and increased thirst*, hypOglycemia, increased Mg/PO4
- hyperkalemia* risk with canagliflozin when used w/other drugs that increase K
