Insulin Secretagogues (SU and Meglitinides)

Question 1

MOA of SU and and Meglitinides

Answer 1

stimulate insulin secretion* from beta cells to decrease POSTPRANDIAL BG*

Question 2

which older 1st generation SU’s have a risk of prolonged hypOglycemia and are SHOULD NOT BE USED

Answer 2

Chlorpropamide

Tolazamide

Tolbutamide

Question 3

list SU agents

Answer 3

*Glipizide (Glucotrol)

*Glimepiride (Amaryl)

*Glyburide, Micronized Glyburide (Glynase)

Question 4

Counseling Points for SU’s and Meglitinides

Answer 4

1. take SU’s w/breakfast, EXCEPT GLIPIZIDE IR* (take 30 min before meals)
2. take meglitinides within 30 min before meals. DO NOT TAKE IF SKIPPING THE MEAL (SKIP DOSE IF SKIP MEAL)
3. can cause hypOglycemia and weight gain*

Question 5

which 2 SU’s are on the BEERS List

Answer 5

Glimepiride and Glyburide due to hypOglycemia risk

Question 6

which SU is an OROS formulation and can leave a GHOST TABLET* (empty shell) in stool

Answer 6

Glucotrol XL (glipizide)

Question 7

pts with what type of deficiency can be at risk for hemolytic anemia with SU’s

Answer 7

G6PD deficiency

Question 8

CI for SU’s

Answer 8

sulfa allergy