GLP-1a/GIP

Question 1

All EXCEPT* which drug has risk of THYROID C-CELL CARCINOMAS*

Answer 1

All except Byetta (exenatide)

Question 2

warnings gor GLP-1a/GIP

Answer 2

PANCREATITIS*, AKI, gallbladder disease

note: (risk factors: gallstones, alcoholism, increased TGs)

Question 3

GLP-1a/GIP are NOT RECOMMENDED for patients who have what

Answer 3

SEVERE GI DISEASE* including gastroparesis* (drug indiced ileus has been reported)

note: Gastroparesis is a condition where the stomach muscles do not function properly, resulting in delayed emptying of food into the small intestine

Question 4

side effects of GLP-1a/GIP

Answer 4

WEIGHT LOSS, NAUSEA, vomiting, diarrhea (reduced with dose titration), hypoglycemia, injection site rxns

Question 5

Special admin considerations:

Q: Byetta directions
Q: Rybelsus directions

Answer 5

1. Byetta, give dose WITHIN 60 MIN BEFORE MEALS*
2. Rybelsus, take dose ≥ 30 min before first food/drink/medications of the day with 4 oz plain water

Question 6

Pen needles are NOT provided with which pens, and why?

Answer 6

needles NOT provided with Victoza (liraglutide) and Byetta (exenatide) because they are administered DAILY**

note: ALL other pens are provided with needles bc they are given WEEKLY*

Question 7

Q: which injection is given BID
Q: Not recommended when CrCl is < ?

Answer 7

1. Byetta (exenatide)
2. Not recommended when CrCl < 30**

Question 8

when is exenatide ER (Bydureon BCise) NOT recommended

Answer 8

not recommended when eGFR < 45*