Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

sft Cytology > sft GYN Cytology > Flashcards

sft GYN Cytology Flashcards

1
Q

Pap adequacy criteria

A

8k-12k cells for conventional paps; 5k cells for liquid-based; unsat if 75% is obscured by inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Adequate number of endocervs to confirm transformation zone sampling

A

at least 10 endocervical or metaplastic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cytotech slide limits and rescreening

A

No more than 100 slides or 8 hours per day; 10% of NILM get screened by 2nd tech

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

High-risk pap criteria (Medicare)

A

Sexually active at <16 yr old >5 sexual partners Hx STD <3 negative paps in past 7 years Daughter of woman who received DES during pregnancy Abnormal pap <3yrs in women of child bearing age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Normal cervical cell components in different hormone states

A

Estrogen therapy/Obesity ↑ superficial cells Progesterone therapy ↑intermediate cells Postmenopausal/Lactation state ↑parabasal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When do you report endometrial cells?

A

>45 years of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Left dx? Right dx?

A

Repair on left; radiation change on right

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pap smear, dx?

A

IUD change

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Buzz word?

A

Atrophic vaginitis; “blue blob”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Trichomonas clinical presentation; associated co-infection? Epithelial changes?

A

Frothy green/yellow discharge, strawberry cervix; Leptothrix; indistinct, small, perinuclear halos (contrast with HPV related koilocytic change)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Left dx? Right dx?

A

Candida on left; Trich on right

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Normal vaginal flora; flora associated with bacterial vaginosis? Cytologic appearance? Clinical association of Actinomyces?

A

Lactobacilli; Coccobacilli/Gardnerella vaginalis (clue cells); long duration of IUD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Left dx? Right dx?

A

left: HSV viral cytopathic effect; right: clue cell (epithelial cell with coccobacilli)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Pap smear, dx? Clinical association?

A

Actinomyces, associated with longstanding IUD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

LSIL criteria and clinical follow-up

A

Nuclear enlargement >3x size of intermediate cell nucleus; nuculear contours smooth or slightly irregular; repeat Pap in 1 year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pap smear, dx?

A

LSIL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Pap smear, dx?

A

NILM, Navicular cells (LSIL mimic) in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

HSIL criteria

A

Small, immature cells with increased N/C ratio and hyperchromatic nuclei with nuclear contour irregularities

19
Q

HSIL rescreening requirements

A

All negative Paps going back 5 years must be rescreened

20
Q

Pap smear, dx?

A

HSIL

21
Q

What’s different between right and left?

A

AIS with feathering on left; HSIL with smooth border on right

22
Q

ASCUS criteria

A

2.5-3x size of intermediate cell nucleus; up to mild variation in nuclear contours; not normal, not enough for LSIL

23
Q

Pap smear, dx?

A

ASCUS

24
Q

ASCH criteria

A

Often used for atypical metaplastic cells; nucleus 1.5-2.5x intermediate nucleus with nuclear changes that fall short of HSIL; hyperchromatic sheets with difficult to visualize details

25
Q

Pap smear, dx?

A

ASCH (atypical metaplastic cells)

26
Q

Pap smear, dx?

A

Squamous cell carcinoma

27
Q

AIS buzz words

A

peripheral feathering; nuclei bulge like a “snake egg” (plus nuclear crowding and hyperchromasia)

28
Q

Pap smear, dx?

A

AIS with peripheral feathering

29
Q

Clues to endocervical adenocarcinoma on pap

A

columnar configuration but with more pleomorphism and loss of polarity; tumor diathesis; this one is well-differentiated but still has features of AIS plus diathesis

30
Q

Pap, dx?

A

IUD change

31
Q

Pap, dx?

A

Arias-Stella reaction

32
Q

Pap, dx?

A

Endometrial adenocarcinoma; bad pleomorphism plus mucus

33
Q

Pap, dx?

A

Arrows are psammoma bodies, in ovarian serous papillary carcinoma

34
Q

What are the HPV genes involved in viral survival, and what host genes do they affect? What HPV gene causes koilocytic change?

A

E6 and E7 inhibit host apoptosis by blocking Rb and p53, leading to carcinogenesis. E4

35
Q

When is HPV testing done? What is the next step if positive or negative?

A

Triage for colposcopy after ASCUS; cotesting for high-risk HPV with cytology in women over 30 (if cyto and HPV are negative, can go longer without screening (3-5 years))

36
Q

Who should get screened for Chlamydia? What are the risks of chlamydia during childbirth?

A

Pregnant women, sexually active <25 years old; women with new or multiple sexual partners; pneumonia and conjunctivitis

37
Q

Anal pap adequacy criteria

A

2,000-3,000 nucleated squamous cells

38
Q

Basic pap guidlines (starting age, interval, etc…)

A

Start at 21 with Paps every 3 years, no HPV testing. At 30, can start cotesting (HPV plus Pap) every 5; Can stop at 65 if no CIN2+ in the last 20 years.; See ASCCP guidelines for detailed algorithms

39
Q

Peritoneal fluid, dx?

A

Endometriosis; glandular and stromal cells in a bloody background.

40
Q

Ascitic fluid, dx?

A

High-grade serous carcinoma with psammoma body (can’t distinguish between primary peritoneal or ovarian in origin)

41
Q

Ascitic fluid, dx?

A

Clear cell carcinoma (ovarian origin); tumor cells with irregular nuclei, vesicular chromatin, prominent nucleoli, and vacuolated cytoplasm

42
Q

Pap smear, dx?

A

LSIL

43
Q

Pap smear, dx?

A

HSIL, keratinizing variant

44
Q

Pap smear, dx?

A

ASCUS

sft Cytology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions