Sexual Development Flashcards

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1
Q

Genetic sex

A

x and y chromosomes

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2
Q

phenotypic sex

A

genitals form between 8-12 weeks

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3
Q

final maturation and sex characteristics continue through _____

A

puberty

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4
Q

Gonads are the same until

A

6 weeks of gestation

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5
Q

2 duct systems

A

wolfian

mullerian

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6
Q

wolfian duct leads to

A

testes

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7
Q

mullarian duct leads to

A

ovaries

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8
Q

which chromosome has the sex determining region (SRY)

A

Y chromosome

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9
Q

SRY produces

A

testes determining factor (TDF)

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10
Q

differentiation of gonads happens at

A

8-12 weeks

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11
Q

leydic cells

A

produce testosterone

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12
Q

Sertoli cells

A

eventually produce sperm

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13
Q

testosterone acts on wolfian ducts to develop ____

A

Internal genitalia (epididymis, seminal
vesicles, vas deferens

Converted to DHT to make penis, scrotum,
and prostate

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14
Q

Sertoli cells secrete ____

A

Mullerian Inhibiting substance/hormone (MIS/MIH) which cause regression of mullerian duct

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15
Q

Anything not conforming to
average patterns are usually
referred to as

A

differences of sex
development (DSD)

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16
Q

which set of chromosomes are sex?

A

23

17
Q

Turner Syndrome

A

45 XO

only one x chromosome so has 45 and not 46

18
Q

Klinefelter syndrome

A

47 XXY

19
Q

Trisomy X - super female

A

47 XXX

20
Q

super male

A

47 XYY

21
Q

Congenital adrenal hyperplasia (CAH)

A

Increase in sex hormone production
from adrenal gland

22
Q

CAH if XX

A

viralized genitals

 Enlarged clitoris, engorged labia
which look like a scrotum

23
Q

CAH if XY

A

viralized genitals

 Often unnoticed until childhood

24
Q

Concerns with CAH

A

changes electrolytes, blood pressure

can cause death of not managed

25
Q

androgen insensitivity syndrome/testicular feminization syndrom (push back)

A

46 XY

Receptors for testosterone do not work

testes does not descend and penis does not grow

External genitalia look like a vulva, short vaginal pouch

No menses, often discovered after puberty