Sex differences Flashcards
types of hormone action
organisational
activational
organisation effects
effects on tissue differentiation and
development
Permanent – long lasting
activational effects
effects that occur in fully developed organism; may depend on prior exposure to organisational effects of hormones
Transient – short term effects
sexual differentiation
Development of sexual dimorphisms
- differences in anatomy, physiology and behaviour between males and females
Sexual differentiation in mammals depends on organisational effects of hormones during development
- 2D-4D ratio
- Facial width to height
genetic basis of sex differentiation
Sex is genetically determined – due to genotype
Diploid human cells contain 46 chromosomes (23 matched pairs):
- 22 pairs of autosomes – don’t determine sex differences – common between genders
- 1 pair of sex chromosomes
gametes
are haploid: just one copy of each chromosome
fuse to create diploid offspring
what is sex determined by?
the male’s gametes (sperm)
SRY (sex-determining region Y) gene a.k.a. testis determining factor (TDF) gene
gonadal sex differentiation
during early embryonic development
- no SRY gene –> no protein = ovaries
- gene –> protein = testis
sets off chain of events that (usually) results in male v female indvs
ovary in development
ovary does not produce significant amounts of steroid hormones during embryonic development
each part of the body develops according to its own intrinsic programme
testis in development
various androgens, incl. testosterone –> masculinises many other tissues, incl. brain
anti-Müllerian hormone (AMH) –> masculinises internal genitalia (a.k.a. Müllerian regression factor)
testosterone
steroid hormone
- fat-soluble, passes readily through cell membrane
primary androgen
synthesised by Leydig cells in testes
Sertoli cells produce AMH
what does testosterone lead to?
dihydrotestosterone (DHT)
phenotypic sex differentiation
Genotypic sex determines gonadal sex
Gonadal sex determines phenotypic sex
Differential exposure to sex steroids during critical periods of development (e.g. foetal development, puberty) causes
- sexual differentiation of the body
- sexual differentiation of the brain and behaviour
These are permanent effects – organisational effects – may then affect how we respond behaviourally to hormones later in development
masculinisation and de-feminisation
Effect of hormone present early in development promotes later development of anatomical or behavioural characteristics typical of males
AMH –> internal genitalia
DHT –> external genitalia
testosterone –> rest of body (inc. brain)
puberty
Further organisational effects of hormones at puberty:
- anterior pituitary releases growth hormone, gonadotropic hormone and adrenocorticotropic hormone
- leads to development of secondary sexual characteristics (not present at birth)
- Primary sexual characteristics = present at birth