sex determination Flashcards

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1
Q

3 weeks (1)

A

PGC’s induced from mesoderm migrate out of the epiblast

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2
Q

6 weeks (2)

A

PGC’s migrate back into the genital ridge

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3
Q

bipotential gonads

A

female/xx/-ovaries male/xy/-testes

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4
Q

genital ridges

A

female- mullerian duct male- wolffian duct

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5
Q

(3) bipotential gonad differentiation

A

gonads determined by embryo chromsome, if xx-ovaries xy-testes

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6
Q

testes MRG

A

SRY

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7
Q

(4) duct development

A

male: testes secrete testosterone and anti mullerian hormone forming wolffian duct female: without testosteorne and AMH wolffian duct deteriorates and mullerian duct forms

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8
Q

wolffian tube derivatives

A

epididymus, vas deferens, seminiferous tubules

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9
Q

mullerian duct derivatives

A

fallopian tubes(oviduct) , uterus, cervix

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10
Q

vas deferens

A

allows sperm and urine out of the body

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11
Q

seminiferous tubules

A

-made of serotoli cells house and nurture sperm to maturation

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12
Q

epididymus

A

holds mature sperm waiting to be ejaculated (lol)

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13
Q

SRY mechanism

A

sry maintains sf1 productio, together they activate sox0

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14
Q

leydig cells

A

make up testes, secrete testosterone

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15
Q

serotoli cells

A

make up the seminiferous tubules, secrete anti mullerian hormone

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16
Q

DHT dependent external structures

A

-scrotum (encapsulates the testes -penis -prostate

17
Q

syncytium

A

connected sperm cells sharing mRNA + proteins from mitosis though full morphogenesis

18
Q
A

sperm: early methylation, but late proliferation and meiosis (doing mitosis for many years)
egg: late methylation but ealy proliferation and paused at prophase of meisosi 1 at birth

females do some of their imprinting and DNA methylation during each cycle (during follicular maturation) but megin meiosis before birth!