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Volatile Anesthetic Agents > Sevoflurane > Flashcards

Sevoflurane Flashcards

1
Q

Sevoflurane Pulmonary Effects

A
  • respiratory depression with very slight tachypnea
  • decreased VT causes minute ventilation and CO2 retention
  • bronchodilation
  • inhibits bronchoconstriction
  • least airway irritant of all inhalation agents
  • great for induction inhalation
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2
Q

Sevoflurane Physical Property: boiling

A

58.5 C

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3
Q

Sevoflurane Physical Property: SVP

A

157 mmHg

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4
Q

Sevoflurane Physical Property: MAC

A

2%

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5
Q

Sevoflurane Physical Property: Blood/Gas Coefficient

A

0.69

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6
Q

Sevoflurane Physical Property: Brain/Blood coefficient

A

1.7

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7
Q

Sevoflurane Physical Property: Muscle/Blood coefficient

A

3.1

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8
Q

Sevoflurane Physical Property: Fat/Blood coefficient

A

48

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9
Q

Sevoflurane Cardiovascular Effects: myocardial contractility

A

dose dependent myocardial contractility, CO and SVR

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10
Q

Sevoflurane Cardiovascular Effects: dilation or constriction?

A

less arterial vasodilation and less decrease in SVR than iso

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11
Q

Sevoflurane Cardiovascular Effects: myocardial contractility

A
  • decrease compared to iso
  • decrease MVo2
  • decrease coronary vascular resistance
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12
Q

Sevoflurane Cardiovascular Effects: SNS

A

does not appear to cause an increase in SNS like des does

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13
Q

Sevoflurane Cardiovascular Effects: steal

A

does not cause coronary artery steal

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14
Q

Sevoflurane Cardiovascular Effects: arrhythmias

A

does not cause them like halothane does

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15
Q

Sevoflurane Neurological Effects: cerebral vessels

A

uncouples auto regulatory response by dilating cerebral vessels

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16
Q

Halothane Neurological Effects: MEP

A

depress MEP monitoring

17
Q

sevo metabolized per renal

A

oxidatively metabolized to hexafluoroisopropanol, formaldehyde, inorganic fluoride and CO2
-increase Fl- can cause renal failure but none reported with sevo

18
Q

sevo and known renal disease

A

does use probably with known or suspected risk for renal damage

19
Q

sevo and Fl- ions in the blood

A

free Fl concentration of 40-50 mcg/L are nephrotoxic

-results in free ions in the blood

20
Q

Renal tubular function and sevoflurane

A

directly inhibits tubular function including Cl transport int he ascending limb of the loop of Henle which leads to concentrating defect

21
Q

obstetrical and N2o

A

decreases activity of methionine synthetase and thymidylate synthetase which is important in RNA/DNA replication patterns
-increased risk of miscarriage prior to scavenger system

Volatile Anesthetic Agents (8 decks)

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