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Volatile Anesthetic Agents > Isoflurane > Flashcards

Isoflurane Flashcards

1
Q

Isoflurane Pulmonary Effects

A
  • respiratory depression
  • less tachypnea than halothane
  • most depression of ventilatory response to hypoxemia and hypercapnia
  • similar impairment of the hypoxic pulmonary vasoconstrictor response
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2
Q

Isoflurane Physical Property: boiling point

A

48.5 C

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3
Q

Isoflurane Physical Property: SVP

A

239.5 mmHg

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4
Q

Isoflurane Physical Property: MAC

A

1.15 %

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5
Q

Isoflurane Physical Property: Blood/Gas Coefficient

A

1.4

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6
Q

Isoflurane Physical Property: Brain/blood coefficient

A

2.6

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7
Q

Isoflurane Physical Property: Muscle/Blood coefficient

A

4

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8
Q

Isoflurane Physical Property: fat/blood coefficient

A

45

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9
Q

Isoflurane Cardiovascular Effects: BP, PVR

A

-dose dependent decrease BP due to decreased vascular resistance

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10
Q

Isoflurane Cardiovascular Effects: CO

A

mild myocardial depress an since cardiac output does not increase in spite of increased LV filling pressure and decreased SVR

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11
Q

Isoflurane Cardiovascular Effects: CO enhanced patients

A

CCB

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12
Q

Isoflurane Cardiovascular Effects: chronotropy

A

negative chronotropic effect on SA node but normal conduction pathways are preserved much better than halothane
-turn iso down and junctional goes away

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13
Q

Isoflurane Cardiovascular Effects: HR

A

increased HR due to indirect activation of the SNS and activation o the ANS and baroreceptor responses to hypotension

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14
Q

Isoflurane Cardiovascular Effects: arrythmogenic

A

nonexistent with iso

-dose of epinephrine needed to induce ventricular arrhythmia is roughly four times that needed with halothane

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15
Q

Isoflurane Cardiovascular Effects: coronary artery

A

vasodilation and decrease coronary vascular resistance

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16
Q

Isoflurane Cardiovascular Effects: MI

A

do not increase the risk of an MI in patients at risk so doesn’t cause coronary artery steal

17
Q

Isoflurane Neurological Effects: CMRO2

A

slight cerebral protection

18
Q

Isoflurane Neurological Effects: EEG

A
  • causes burst suppression at 1.5 MAC

- electrical silence at 2 MAC

19
Q

Isoflurane Neurological Effects: MEPs

A

no effect

20
Q

isoflurane neuro effects: MEPs

A

does not effect

21
Q

iso hepatic metbolism

A

0.2%

22
Q

iso hepatic blood flow

A

preserve hepatic artery blood flow better than halothane so better O2 supply than halothane

Volatile Anesthetic Agents (8 decks)

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