Session 8 Flashcards
Where is the pituitary gland located?
Beneath the hypothalamus in a socket of bone called the sell turcica
What is the name given to the socket of bone where the pituitary gland sits?
Sella turcica
Where is the pituitary gland located in relation to the hypothalamus?
Below the hypothalamus
The hypothalamus and pituitary gland form a functional unit that serves as a link between…
The endocrine and nervous systems
The pituitary gland consists of how many parts? Name them
2 parts
Anterior pituitary gland
Posterior pituitary gland
Describe the embryological origins of the…
I) anterior pituitary
II) posterior pituitary
Arises from evagination of oral ectoderm
Arises from neuroectoderm
What is oral ectoderm?
Primitive gut tissue (ap arises from this)
What is neuroectoderm?
Primitive brain tissue (pp arises from this)
Which parts of the pituitary gland are physically connected to the hypothalamus?
Posterior Pituitary Gland
The hypothalamus drops down through the ________________ to form the posterior pituitary
Infundibulum
What is the colloquial name for the infundibulum?
Pituitary stalk
Where is oxytoxin and ADH produced?
By neurosecretory cells in the supraoptic and paraventricular nuclei of the hypothalamus
Oxytocin and ADH are produced by neurosecretory cells of which parts of the hypothalamus?
Supraoptic and paraventricular nuclei
Oxytocin and ADH produced in the supraoptic/paraventricular nuclei of the hypothalamus are transported down nerve cell axons to the…
Posterior pituitary
How is oxytocin/ADH transported from the hypothalamus to the posterior pituitary?
Down nerve cell axons
Where is oxytocin and ADH…
I) produced
II) stored
III) released into the general circulation
Hypothalamus - supraoptic/paraventricular nuclei
Posterior pituitary
Posterior pituitary
The ADH and oxytocin released form the posterior pituitary act on…
Distant targets
Hormones synthesised in hypothalamus are transported down axons and stored in the…
…before being released into the hypophyseal portal system
Median eminence
Hormones for stimulation of the anterior pituitary are synthesised in the ______________, stored in the ___________ __________ and then released into the…
Hypothalamus
Median eminence
Hypophyseal portal system
What is the function of the hormones released from the hypothalamus for action on the anterior pituitary?
What name is given to this type of cell/hormonal communication?
They stimulate/inhibit target endocrine cells in the anterior pituitary
Neurocrine function
Describe the endocrine function of the anterior pituitary
Endocrine cells in the anterior pituitary secrete a variety of hormones into the bloodstream that act on distant sites
Does the anterior pituitary have autocrine/paracrine functions?
Yes - hormones released from the anterior pituitary effect neighbouring cells
Hormones are produced by __________ cells in the hypothalamus
Nerve
Hormones secreted exclusively into the hypophyseal portal system affect _____________ cells within the _____________ ___________
Endocrine
Anterior pituitary
Which hormones are produced in the hypothalamus for release from the posterior pituitary?
Oxytocin
ADH
What is the function of oxytocin? Where is it released?
Milk let down and uterus contractions during birth
Posterior pituitary
What is the function of ADH? Where is it released?
Regulation of body water volume
Posterior pituitary
The tropic hormones of the hypothalamus have direct effects on the release of other anterior pituitary hormones. What is meant by the term tropic?
Affects the release of other hormones in the target tissue (anterior pituitary)
How many tropic hormones are produced in the hypothalamus for effect on the anterior pituitary?
6
Name the 6 tropic hormones produced in the hypothalamus for effect on the anterior pituitary
TRH - thyrotropin releasing hormone PIH - prolactin release-inhibiting hormone CRH - corticotropin releasing hormone GnRH - gonadotropin releasing hormone GHRH - growth hormone releasing hormone GHIH - growth hormone inhibiting hormone
Somatostatin is also known as…
Growth hormone inhibiting hormone
Dopamine is also known as…
Prolactin release-inhibiting hormone
Which 6 hormones are released from the anterior pituitary?
TSH - thyroid stimulating hormone FSH - follicle stimulating hormone GH - growth hormone ACTH - adrenocorticotropic hormone PL - prolactin LSH - luteinising hormone
What is the function of TSH?
Secretion of thyroid hormone from thyroid gland
What is the function of adrenocorticotropic hormone (ACTH)?
Secretion of hormones from adrenal cortex (cortisol)
What is the function of luteinising hormone?
Ovulation and secretion of sex hormones
What is the function of follicle stimulating hormone?
Development of eggs and sperm
What is the function of prolactin?
Mammary gland development and milk secretion
What is the function of growth hormone?
Growth and energy metabolism
Growth hormone stimulates…
IGFs
Insulin-like Growth Factors
TRH released from the hypothalamus activates which hormone in the anterior pituitary?
What does this hormone released from the anterior pituitary act on?
TSH
Thyroid gland
Which hormone from the hypothalamus results in the release of ACTH from the anterior pituitary?
ACTH released from the anterior pituitary acts on…
CRH
Adrenal cortex
Which hormones affect the release of prolactin from the anterior pituitary? What effect does each have?
Prolactin acts on which gland?
PIH (inhibit)
TRH (stimulatory)
Mammary gland
What hormones in the anterior pituitary does GnRH act on?
What parts of the body do these hormones released from the anterior pituitary act on?
LH
FSH
The pathways by which hypothalamic and anterior pituitary hormones are produced is often regulated by…
Negative feedback
What is apoptosis?
Programmed cell death - cell death by shrinkage
What is necrosis?
Cell death by damage
What is atrophy?
Decrease in cell number/size
What is hyperplasia?
Increase in cell number
What is hypertrophy?
Increase in cell size
What is the most important endocrine regulator of postnatal growth?
Growth hormone
State 4 factors that influence growth…
Genetics
Environment
Nutrition
Hormones
Where is growth hormone produced?
In the anterior pituitary
What hormone stimulates the release of growth hormone?
What hormone inhibits the release of growth hormone?
GHRH
GHIH
What type of hormone is growth hormone?
PEPTIDE HORMONE - protein hormone consisting of a single peptide
The growth-promoting effects of growth hormone are mainly excreted indirectly via…
Insulin-like growth factors
In response to growth hormone, cells of the liver and skeletal muscle produce/secrete…
Insulin-like growth factors
What role does growth hormone and the IGFs they act via have during childhood and teenage years?
It is essential for NORMAL growth
GH —> Long bone development
IGFs —> Bone + Cartilage growth
What role does GH and IGFs play in adults?
Helps maintain muscle/bone mass and promotes healing and tissue repair
What role does GH specifically have in children?
Involved in long bone development
What role do IGFs as a result of GH specifically have in children?
Involved in both bone + cartilage growth
Control of GH secretion is principally via the…
Hypothalamus and secretion of GHRH/GHIH
What role does the CNS play in the control of GH secretion?
Regulates GH secretion via inputs into the hypothalamus affecting GHRH/GHIH levels
Name two things that can result in increased GH secretion?
Onset of deep sleep
Stress
Exercise
Fasting