Session 12 L1: Depression Flashcards

1
Q

What are the core symptoms for depression

A
  • Low mood
  • Lack of Energy
  • Lack of enjoyment & interest
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2
Q

What are other symptoms of depression?

A
  • Depressive thoughts

- Somatic symptoms/Biological symptoms

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3
Q

What are features of adjustment reaction in comparison to depression?

A

Adjustment

  • Symptoms develop sudden after and ‘event’
  • Symptoms fluctuate
  • Time limited
  • Preoccupation with ‘event’
  • Energy not low
  • No particular pattern to sleep disturbance
  • Reduced or increased appetite
  • Feelings of anger and frustration more typical
Depression
-Symptoms develop gradually
-Symptoms continuous
Usually at last two weeks
-Lack of interest 
-Low energy
-Sleep disturbance with typically EMW
-Loss of appetite and weight loss are typical
-Low self-esteem and feelings of guilt and blame are typical
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4
Q

What defines our personality?

A
  • How we get on with people, ability to make relationships
  • Extrovert or introvert
  • How empathetic we are
  • How anxious and nervous we are; or how confident
  • How we can make plans and stick to these plans
  • How we respond in stressful circumstances
  • Our overriding mood

Some people have a sense of not being happy within themselves, sometimes related to a feeling of emptiness. This does not necessarily mean that they are depressed

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5
Q

What are examples of physical disorder causing depressive disorders?

A
  • Hormone disturbance such as thyroid dysfunction
  • Vitamin deficiencies such as vitamin B12
  • Heart and Lung disease
  • Blood vessels not functining well
  • Kidney disease
  • Liver Disease
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6
Q

What substances can cause Depression?

A

Alcohol and Drug misuse

  • People drinking too much over a period is a well-known cause of developing depressive symptoms.
  • A number of recreational drugs cause depressive symptoms, especially drugs that initially induce a feeling of happiness and wellbeing such as XTC or amphetamines
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7
Q

What is are the component of the limbic system?

A
  • Cingulate gyrus
  • Hippocampus
  • Amygdala
  • Hypothalamus
  • Septum
  • Olfactory Bundle
  • Dentate Gyrus
  • Anterior Nucleus of the Thalamus
  • Mammillary Bodies
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8
Q

What is the function of the limbic system?

A
  • Emotion
  • Motivation
  • Memory
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9
Q

What conditions are due to disruption in the function of the basal ganglia?

A
  • Parkinson’s disease
  • Wilson’s disease
  • Huntington’s disease
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10
Q

What is the function of the basal ganglia?

A
  • Motor function; malfunction of the basal ganglia are implicated in neurological illnesses
  • Emotion
  • Cogntion
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11
Q

What is the main hypothesis of mood?

A

Determined by functional circuits between these brain areas e.g. the frontal lobe projects to parts of the limbic system which in turn connects to the basal ganglia and the brainstem.

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12
Q

What does do the circuits affect?

A
  • Cognitive processed (thoughts)
  • Sympathetic output
  • Parasympathetic output
  • Motor systems
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13
Q

What are the 2 main neurotransmitters in psychiatric disorders?

A
  • Norepinephrine

- Serotonin

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14
Q

Where is norpehnerphrine made and what does it act on?

A
  • Made in the locus coerulus in the brainstem and transported to several areas of the cortex
  • Acts on 4 types of receptors which are α1, α2, β1, β2. α1 for arousal and mood
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15
Q

What is the function of norepinerphine in the brain?

A
  • Mood
  • Suggests a role in behaviours (arousal and attention)
  • Implicated in memory functions
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16
Q

Where is serotonin made?

A
  • Produced in the brain stem (Raphe nuclei) and transported to cortical areas and limbic system
  • Complex receptor organisation with many different pre and post serotonergic receptors
17
Q

What are the function of serotonin in the brain?

A
  • Sleep
  • Impulse control
  • Appetite
  • Mood
18
Q

What are the other neurotransmitters that are important in psychiatric conditions?

A
  • Dopamine
  • Acetylcholine
  • GABA
  • Glutamate
19
Q

What is the evidence of noradrenaline being implicated in the causation of depression?

A
  • AMPT inhibits Tyrosine to L-DOPA. So sleep, anger, calmness and depressive symptoms
  • Anti-depressants (NARI - Has no effect, Tricyclin anti-depressants, SNRI’s)
20
Q

What is the evidence of serotonin being implicated in depression?

A
  • 5HIAA depletion in CSF (a metabolite of serotonin) in patients with depression
  • Tryptophan depletion (precursor for serotonin) causes depression
  • PET and SPET studies
  • Reserpine depletes nerve endings from mono amines
  • Antidepressants: SSRI, TCA, SNRI’s, MAOI used in moderate to severe depression as more effect
21
Q

What causes clinical depression?

A
  • Predisposing: genetics, childhood experiences, female gender
  • Perpetuating: stressful Job, studies, selationship Difficulties, substance Misuse, financial strain, housing, unemployment
  • Precipitating factors: Life events often related to losses such as loss of someone you love, loss of health and break up of relationships
22
Q

What are the approaches to treatment of Depression?

A
  • Medication (direct effect on biochemistry of the brain)

- Social and psychological interventions such as CBT – have a measurable effect on the biochemistry of the brain