Session 10_Respiratory System and Gas Exchange Flashcards
What is emphysema?
lung condition characterized by an abnormal, permanent enlargement of the air spaces distal to the terminal bronchioles accompanied by destruction of their walls.
Why are people with emphysema short of breath?
(irreversible alveolar damage resulting in loss of elastic recoil and the normal tethering of the alveolar, which renders the lung parenchyma excessively compliant and floppy. Excessive distension and dilatation of the terminal bronchioles and destruction of alveoli reduce the surface area for gas exchange. –> diffusing capacity is reduced.
Dead space in lungs and TLC increase.
Breathing at normal tidal volume, the pts airways close beyond the degree normally occurring with aging, contributing to ventilation and per-fusion mismatch and hypoxemia.
What causes emphysema?
prolonged history of smoking and chronic bronchitis. indicates significant irreversible lung damage.
Diffusion =
process of randomly moving molecules making their way back and forth across the respiratory membrane
What determines movement of gases?
concentration; high –> low
Dalton’s law of PP =
Ptotal = P1+ P2+ P3.. etc
What type of motion does diffusion require?
molecular motion
What gases are in the atmospheric pressure?
oxygen, nitrogen, carbon dioxide and water
How much oxygen is in the atmospheric pressure?
20.84% of 760mmHg = (158.384mmHg)
How much nitrogen is in the atmospheric pressure?
78.62% of 760mmHg = (597.512mmHg)
How much carbon dioxide is in the atmospheric pressure?
0.04% of 760mmHg = (.304mmHg)
How much water is in the atmospheric pressure?
0.5% of 760mmHg = (3.8mmHg)
Pressure creates a ___________ impact on the surface
molecular
Partital pressure =
multiple gases in air
Each gas exerts a pressure (partial pressure of whole); rate of diffusion is directly related to:
partial pressure of a gas
Total pressure at sea level =
760mmHg
Gases dissolved in fluids continue to:
exert forces
Partial pressure of a gas in fluid is determined by:
- concentration
* solubility coefficient of the gas
solubility coefficient of the gas is related to the partial pressure which is equal to =
concentration of dissolved gas / (divided by) solubility coefficient
What is the solubility coefficient of atmospheric O2?
0.024
What is the solubility coefficient of CO2?
0.57
Alveolar gas and molecules of same gas dissolved in:
blood
What will be the direction of the net diffusion of the gas?
depends on multiple factors.
What factors does net rate of diffusion depend on?
- pressure difference
- solubility of the gas in the fluid
- cross-sectional area of the fluid
- distance the gas must diffuse
- molecular weight of the gas
- temperature of the fluid
Gas diffusion (D) is proportional to:
∆ P x A (cross sectional area) x S (solubility) / d (distance of diffusion) x square root of MW (molecular weight)
∆ P x A x S / d x √MW
PP difference –>
PP @ arterial end and PP @ venous end
Diffusion coefficient =
relative rate that gases @ same PP will diffuse
Diffusion coefficient of oxygen =
1
Diffusion coefficient of carbon dioxide =
20.3
Diffusion coefficient of carbon monoxide =
0.81
Diffusion coefficient of nitrogen =
0.53
Diffusion coefficient of helium =
0.95
Diffusion coefficients give us a method by which to:
interpret how gases diffuse in water and/or blood
Respiratory gases are very soluble in lipids; therefore ___________________________________________.
Diffusion across membranes occurs relatively easily
What is a limiting factor for the rate of diffusion?
through tissue water
Rate of diffusion through tissues ≈
diffusion through water
O2 is constantly being:
constantly being absorbed from alveoli
CO2 is constantly being:
constantly diffusing from blood into alveoli
In H2O,
air is humidified in respiratory tract (water vaporizes) AND PH2O at body temperature = 47mmHg
What makes the concentrations different between atmospheric air and alveolar air differ?
O2, CO2, H2O, and N2
N2 makes up the balance of total atmospheric air at :
760mmHg
Can alveolar air be higher than atmospheric air?
NO
Know slide 16
Know slide 16
At what location is N2 highest?
in atmospheric air, @ 597mmHg
At what location is O2 highest?
in atmospheric air, @ 159mmHg
At what location is CO2 highest?
in alveolar air, @ 40mmHg
At what location is H20 highest?
same in humidified, alveolar and expired air, @ 47mmHg
At what location is N2 lowest?
in humidified air @ 563.4 mmHg
At what location is O2 lowest?
in alveolar air @ 104 mmHg
At what location is CO2 lowest?
in atmospheric and humidified air, @ 0.3 mmHg
At what location is H20 lowest?
in atmospheric air, @ 3.7mmHg
We get partial replacement of alveolar air when?
with each breath
New air into alveoli with each breath ≈
305ml (same amount of old air expired)
_____ alveolar air replaced by new air each breath.
1/7
What is the significance of alveolar air replacement?
to maintain balance of O2 and CO2
Alveolar oxygen concentration is controlled by:
rate of absorption AND rate of oxygen entry
Rate of absorption by pulmonary capillaries =
amount leaving the alveoli
Rate of oxygen entry into alveoli via ventilation =
amount entering the alveoli
PO2 in alveoli can never exceed?
149mmHg at sea level (if individual is breathing normal atmospheric air)
Why can’t alveoli exceed 149 mmHg???
??
Explain figure on slide 19
Explain figure on slide 19
Know figure on slide 20
Know figure on slide 20
In the respiratory membrane, diffusion of gases occurs very rapidly: large surface area of respiratory membrane with _________ amount of ________ spread throughout
small
blood
At the respiratory membrane, what size diameter are the pulmonary capillaries?
small
In the respiratory membranes gases travel from _______________________________.
one capillary to the next
Diffusion of gases through the respiratory membrane is similar to:
diffusion of gases through water
Diffusion of gases through the respiratory membrane is affected by:
• _______________ of membrane
• _______________of respiratory membrane
• _______________ coefficient
• _______________ difference across the membrane
- THICKNESS of membrane
- SURFACE AREA of respiratory membrane
- DIFFUSION coefficient
- PRESSURE difference across the membrane
What is the respiratory membrane’s diffusion capacity?
volume of a gas that will diffuse through the membrane each minute for a partial pressure difference of 1 mmHg
see slide 24
see slide 24
Va / Q normal =
Va for an alveolus is normal and Q is normal for the same alveolus
(4/5) = 0.8
Va/Q (0/5) =
(0/5) =0
Va is zero and there is blood flow
ex: holding breath // not breathing
Va/Q (4/0) =
(4/0) = ∞
Va (breathing) is adequate and there is no blood flow (ex: short lives situation –> ischemia)
Va =
Q =
ventilation
perfusion
Does gas exchange occur if ratio is zero or infinity?
no