Serotonin Syndrome Flashcards
1
Q
What causes serotonin syndrome?
A
The use of multiple medications that increase the amount of serotonin at the synaptic cleft
eg SSRI's + TCA SSRI's + MAOi SSRI's + lithium SSRI + Clomipramine
2
Q
How does SS present?
A
Cardio: Tachycardia, sweating, increase or decreased BP, flushing
Neurology: Tremor, hyperreflexia, myoclonus, delirium, seizures
Gastro: Nausea, vomiting, diarrhoea, abdo pain
3
Q
How do you differentiate NMS from SS?
A
History: Which agents they’ve taken
Examination: NMS has hyporeflexia and cogwheeling/lead pipe rigidity whereas SS has hyperreflexia and clonus
4
Q
What is clonus?
A
Involuntary, rhythmic muscular contractions and relaxations
5
Q
What are the treatment of SS?
A
Crypohepatine
Clompromazine
Propranolol
