Mood Disorders Flashcards

1
Q

What is an emotion?

A

A complex action that includes things like facial expression, posture, and internal milieu that is accompanied by thought process

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2
Q

What are feelings?

A

Affect or presentation of an emotion

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3
Q

What is mood vs affect?

A

Mood is the subject aspect of a person feeling state, it is more the climate of the feeling

Affect is the more objective aspect, it is also the moment by moment expression of feeling eg weather

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4
Q

What are mood disorder more broadly?

A

Disorder in normal mood, whether lower or higher

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5
Q

What are the cardinal symptoms for depression diagnosis?

A

> 2 weeks duration of: must have at least one of

  • Depressed mood - of a particular quality, with loss of reactivity, and classically in a diurnal pattern (worse in the morning, better at night)
  • Anhedonia
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6
Q

What is reactivity?

A

The response of a person to events eg laughing at sometime funny, sadness towards an event

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7
Q

What are the neuro-vegetative secondary symptoms for depression diagnosis?

A
  • Sleep disturbance
  • Appetite disturbance
  • PSYCHOMOTOR RETARDATION
  • Impaired concentration, set shifting, rumination
  • Working memory deficits
  • Libidinal changes
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8
Q

What are the cognitive-affective symptoms of depression?

A
  • Anxiety
  • Helplessness
  • Loss of self esteem, WORTHLESSNESS
  • Social withdrawal
  • Depersonalisation, derealisation
  • GUILT
  • Shame
  • Rage
  • Nihilism
  • Hopelessness
  • Suicidal ideation
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9
Q

What are the psychotic symptoms of depression?

A
  • Hallucinations

- Delusions

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10
Q

What is characteristic of psychotic depressive symptoms?

A

Mood congruent - will match the mood

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11
Q

What is the likelihood that a depressive episodes will recur?

A

50%

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12
Q

What is the rate of postpartum depression?

A

~10% of mothers, 1/2 that will be severe

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13
Q

What is the recurrence rate of postpartum depression?

A

50%

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14
Q

How is depression in the elderly different?

A

Somatic symptoms often predominate
Organic conditions are common
Often precipitated by loss

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15
Q

What are some medical causes of depression?

A
Hypothyroidism
Cushing's 
Ca
MS
HIV
Stroke (especially involving left frontal pole)
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16
Q

Which medications can trigger or exacerbate depression?

A
Monoamine depletion
Corticosteroids - dose effect 
GABA-ergic drugs - benzodiazepines, alcohol
Chemotherapy
OCP (rare)
Interferon
17
Q

How do you differentiate grief from depression?

A
  • Duration of symptoms >6 months, grief is usually better
  • In grief, the sadness is focussed on the object of loss
  • Grief feels like a transient process
18
Q

How heritable is depression?

A
  • Moderately

- Genes increase our sensibility to life events

19
Q

How might patients with depression brain appear?

A

Smaller hippocampus

Larger ventricles

20
Q

What are some psychosocial risk factors for depression?

A

Parental loss + poor parenting afterwards
Chronic exposure to severely depressed mothers
Childhood sexual abuse
1 good relationship & a higher IQ is protective
Confiding other is very protective

21
Q

What are some precipitating event types?

A

Loss
Humiliation
Entrapment
Danger

22
Q

What are some protective environmental factors?

A

Employment and financial independence

Neutralising or fresh start events

23
Q

What is the anaclitic personality?

A

Exaggerated need for relatedness, preoccupation, entanglement

24
Q

What is the introjective personality?

A

Independent, autonomy

25
Q

What are some psycho-social treatment for depression?

A
CBT
IPT
Couple therapy
Psychodynamic - more complex depression
Exercise
Sleep, diet, alcohol reduction
Confiding other
26
Q

What are some pharmacological treatment for depression?

A
SSRI's - sertraline, escitalopram, fluoxetine
SNRI's - venlafaxine, duloxetine
Mirtazepine
TCA - Nortriptyline, imipramine 
Lithium 
Thyroxine
Second generation anti-psychotic
27
Q

How long do you continue therapy?

A

6-12 months at the full treatment dose for the 1st episode

Indefinite if 2nd or 3rd treatment

28
Q

When is ECT useful?

A
Melancholic
Psychotic 
Puerperal/postpartum  
Bipolar depression or mania 
Prominent suicidality 
Poor oral intake