Serotonin Syndrome Flashcards
1
Q
What is serotonin syndrome?
A
A potentially life threatening condition associated with increased serotoninergic activity in the central nervous system.
2
Q
What are the main causes of Serotonin Syndrome?
A
monoamine oxidase inhibitors
SSRIs
ecstasy
amphetamines
3
Q
How can SSRI’s cause serotonin syndrome?
A
St John’s Wort, often taken over the counter for depression, can interact with SSRIs to cause serotonin syndrome
4
Q
How does serotonin syndrome present?
A
neuromuscular excitation: ---hyperreflexia ---myoclonus ---rigidity autonomic nervous system excitation: ---hyperthermia ---sweating altered mental state: ---confusion
5
Q
What is the main management of serotonin syndrome?
A
Supportive- IV fluids
Benzodiazepines
6
Q
What are severe cases of serotonin syndrome managed with?
A
Serotonin antagonists
—Cyproheptadine
—Chlorpromazine
