Benzodiazepines Flashcards
What is the mechanism of action of benzodiazepines?
They enhance the effect of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by increasing the frequency of chloride channels.
What are the main uses of benzodiazepines?
Insomnia and Parasomnia
Seizures (alcohol withdrawal)
What do patients commonly develop when taking Benzodiazepines?
Tolerance and Dependence
How long are Benzodiazepines commonly prescribed?
a short period of time (2-4 weeks)
Why should Benzodiazepines be withdrawn in steps?
To prevent patient developing benzodiazepine withdrawal syndrome
When does Benzodiazepine withdrawal syndrome typically occur?
Up to 3 weeks after stopping a long acting drug
What is Benzodiazepine withdrawal syndrome similar to?
Alcohol withdrawal syndrome
How does Benzodiazepine withdrawal syndrome present?
- insomnia
- irritability
- anxiety
- tremor
- loss of appetite
- tinnitus
- perspiration
- perceptual disturbances
- seizures
What are examples of Benzodiazepines?
Diazepam
Lorazepam
Chlordiazepoxide
What perceptual disturbance can benzodiazepines cause?
Anterograde amnesia
