Antidepressants- Tricyclic Antidepressants Flashcards
What were Tricyclic Antidepressants typically used for?
Depression
Why are Tricyclic Antidepressants now less commonly used?
Side-effects
Toxicity overdose
What are Tricyclic Antidepressants typically used for now?
Neuropathic pain
Why are Tricyclic Antidepressants now more commonly used for neuropathic pain?
Smaller doses are typically required
What are the common side effects of Tricyclic Antidepressants?
- drowsiness
- dry mouth
- blurred vision
- constipation
- urinary retention
- lengthening of QT interval
What is low-dose amitriptyline commonly used for?
- The management of neuropathic pain
* The prophylaxis of headache (both tension and migraine)
What is the mechanism of tricyclic antidepressants?
They increases serotonin, noradrenaline and dopamine
What is the major problem with tricyclic antidepressants?
Lengthening of the QT interval, even at therapeutic level
What are the 2 types of Tricyclic Antidepressants?
Secondary
Tertiary
Which drugs are tertiary tricyclic antidepressants?
Imipramine
Amitriptyline
Doxepin
Clomipramine
Which drugs are secondary tricyclic antidepressants?
Desipramine
Nortriptyline
Which tricyclic antidepressants are more sedative?
- Amitriptyline
* Clomipramine
Which tricyclic antidepressants are less sedative?
- Imipramine
- Lofepramine
- Nortriptyline
