Serotonin Block 3

Question 1

what is serotonin formed from

Answer 1

L-tryptophan

Question 2

what is serotonin a precursor for

Answer 2

melatonin

Question 3

what inactivates serotonin

Answer 3

MAO

Question 4

rate limiting step in serotonin synthesis

Answer 4

tryptophan hydroxylase

Question 5

what is the enzyme in the serotonin synthesis that also converts L-DOPA into dopamine

Answer 5

L-aromatice a.a. decarboxylase

Question 6

what are the 3 sites for serotonin synthesis

Answer 6

CNS
Platelets
Entero-Chromaffin cells in GI

Question 7

what is the serotonin receptor that is inotropic on the heart

Answer 7

5HT3

Question 8

5HT1 and 5HT5 are inhibitory for what

Answer 8

serotonin (decrease cAMP)

Question 9

5HT1 and 5HT5 is excitatory for wat

Answer 9

dopamine

Question 10

what are the agonist for 5HT1-a receptro

Answer 10

• antidepressants
• anytpsychotics
• ergotamines
• hallucinogens

Question 11

agonist for 5HT1-B

Answer 11

tryptans and ergotamines

Question 12

agonist for 5HT - 1d

Answer 12

tryptans and ergotamines

Question 13

agonist for 5HT-2A

Answer 13

LSD
Mescaline
Psilocybin

Question 14

antagonist for 5HT-2A

Answer 14

antipsychotics and antidepressants

Question 15

agonist for 5HT-2B

Answer 15

fenfluramine

MDMA

Question 16

antagonist for 5HT-2B

Answer 16

GI meds
methysergide
antihypertensives ( serins)

Question 17

5HT-3 agonist

Answer 17

BZP

Question 18

5HT-3 antagonist

Answer 18

antipsychotics, antiemetics, and metoclopramide

Question 19

5HT 2C agonist

Answer 19

aripiprazole and trazodone

Question 20

5HT 2C antagonist

Answer 20

antidepressants
antipsychotics
SSRI’s
Ritanserin

Question 21

which 5HT receptors are auto receptors

Answer 21

5HT1

Question 22

which serotonin receptors are on dendrites and influence action potential by inhibiting it

Answer 22

5HT-1A

Question 23

antidepressants are antagonist to what

Answer 23

5HT2A and 5HT2C

Question 24

what do antidepressants increase

Answer 24

NE

Question 25

antidepressants are against for what

Answer 25

5HT1A

Question 26

why are antipsychotics " not clean" drugs

Answer 26

because they affect other receptors not just serotonin like DOPAMINE ACH..

Question 27

many of the drugs that affect 5HT receptors also affect what

Answer 27

appetite | enterochromaffin cells and vominting center in medulla

Question 28

what serotonin receptors influence vasoconstriction

Answer 28

5HT1B 5HT1D 5HT2 5HT7

Question 29

what are two antihypertensives that inhibit the vasoconstriction of serotonin receptors

Answer 29

Ketanserin and Ritanserin

Question 30

What do -triptans do

Answer 30

they are agonist for 5HT receptors and cause vasoconstriction

Question 31

what is the UDE of -triptans

Answer 31

they can make vasoconstriction of other vessels like the heart or in the GI

Question 32

-triptans are contraindicated in who

Answer 32

coronary heart problems

Question 33

what triptan is the one with a nasal spray option

Answer 33

Zolmitriptan

Question 34

what are the 3 drugs that are mixed agonist and antagonist

Answer 34

Renzapride Cisapride Metoclopramide

Question 35

what agonist/antagonist causes prolong QT

Answer 35

renzapride

Question 36

what is metoclopramide an antagonist of

Answer 36

Dopamine D2 receptor

Question 37

serotonin can activate other platelets how and also cause vasoconstriction

Answer 37

by binding to 5HT2A

Question 38

how does serotonin cause NO release

Answer 38

by binding to 5HT1

Question 39

NT involved in emotion and reward

Answer 39

Dopamine

Question 40

NT involved in arousal, wakefulness, mood, and heart regulation

Answer 40

NE

Question 41

NT involved in arousal, short term memory and learning

Answer 41

ACH

Question 42

NT involved in temperature control, sensory pathways, mood and emotion regulation and sleep/wakefulness?

Answer 42

serotonin

Question 43

what NT mediates the majority of inhibitory postsynaptic potentials

Answer 43

GABA

Question 44

what NT increases CLflux into into the postsynaptic neuron and results in hyperpolarization

Answer 44

glycine

Question 45

what NT mediates excitatory NA influx into the posthypnotic neuron

Answer 45

glutamate

Question 46

what mediates pain in the spinal cord

Answer 46

substance P