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Pharmacology > Serotonin Block 3 > Flashcards

Serotonin Block 3 Flashcards

1
Q

what is serotonin formed from

A

L-tryptophan

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2
Q

what is serotonin a precursor for

A

melatonin

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3
Q

what inactivates serotonin

A

MAO

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4
Q

rate limiting step in serotonin synthesis

A

tryptophan hydroxylase

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5
Q

what is the enzyme in the serotonin synthesis that also converts L-DOPA into dopamine

A

L-aromatice a.a. decarboxylase

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6
Q

what are the 3 sites for serotonin synthesis

A

CNS
Platelets
Entero-Chromaffin cells in GI

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7
Q

what is the serotonin receptor that is inotropic on the heart

A

5HT3

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8
Q

5HT1 and 5HT5 are inhibitory for what

A

serotonin (decrease cAMP)

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9
Q

5HT1 and 5HT5 is excitatory for wat

A

dopamine

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10
Q

what are the agonist for 5HT1-a receptro

A
  • antidepressants
  • anytpsychotics
  • ergotamines
  • hallucinogens
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11
Q

agonist for 5HT1-B

A

tryptans and ergotamines

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12
Q

agonist for 5HT - 1d

A

tryptans and ergotamines

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13
Q

agonist for 5HT-2A

A

LSD
Mescaline
Psilocybin

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14
Q

antagonist for 5HT-2A

A

antipsychotics and antidepressants

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15
Q

agonist for 5HT-2B

A

fenfluramine

MDMA

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16
Q

antagonist for 5HT-2B

A

GI meds
methysergide
antihypertensives ( serins)

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17
Q

5HT-3 agonist

A

BZP

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18
Q

5HT-3 antagonist

A

antipsychotics, antiemetics, and metoclopramide

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19
Q

5HT 2C agonist

A

aripiprazole and trazodone

20
Q

5HT 2C antagonist

A

antidepressants
antipsychotics
SSRI’s
Ritanserin

21
Q

which 5HT receptors are auto receptors

A

5HT1

22
Q

which serotonin receptors are on dendrites and influence action potential by inhibiting it

A

5HT-1A

23
Q

antidepressants are antagonist to what

A

5HT2A and 5HT2C

24
Q

what do antidepressants increase

A

NE

25
Q

antidepressants are against for what

A

5HT1A

26
Q

why are antipsychotics “ not clean” drugs

A

because they affect other receptors not just serotonin like DOPAMINE ACH..

27
Q

many of the drugs that affect 5HT receptors also affect what

A

appetite

enterochromaffin cells and vominting center in medulla

28
Q

what serotonin receptors influence vasoconstriction

A

5HT1B
5HT1D
5HT2
5HT7

29
Q

what are two antihypertensives that inhibit the vasoconstriction of serotonin receptors

A

Ketanserin and Ritanserin

30
Q

What do -triptans do

A

they are agonist for 5HT receptors and cause vasoconstriction

31
Q

what is the UDE of -triptans

A

they can make vasoconstriction of other vessels like the heart or in the GI

32
Q

-triptans are contraindicated in who

A

coronary heart problems

33
Q

what triptan is the one with a nasal spray option

A

Zolmitriptan

34
Q

what are the 3 drugs that are mixed agonist and antagonist

A

Renzapride
Cisapride
Metoclopramide

35
Q

what agonist/antagonist causes prolong QT

A

renzapride

36
Q

what is metoclopramide an antagonist of

A

Dopamine D2 receptor

37
Q

serotonin can activate other platelets how and also cause vasoconstriction

A

by binding to 5HT2A

38
Q

how does serotonin cause NO release

A

by binding to 5HT1

39
Q

NT involved in emotion and reward

A

Dopamine

40
Q

NT involved in arousal, wakefulness, mood, and heart regulation

A

NE

41
Q

NT involved in arousal, short term memory and learning

A

ACH

42
Q

NT involved in temperature control, sensory pathways, mood and emotion regulation and sleep/wakefulness?

A

serotonin

43
Q

what NT mediates the majority of inhibitory postsynaptic potentials

A

GABA

44
Q

what NT increases CLflux into into the postsynaptic neuron and results in hyperpolarization

A

glycine

45
Q

what NT mediates excitatory NA influx into the posthypnotic neuron

A

glutamate

46
Q

what mediates pain in the spinal cord

A

substance P

Pharmacology (4 decks)

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