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Pharmacology > Autonomic Drugs > Flashcards

Autonomic Drugs Flashcards

1
Q

Nicotine

A

ganglionic stimulant

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2
Q

lobeline

A

g. stimulant

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3
Q

tetramethyl ammonium TTMA)

A

g. stimulant

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4
Q

DMPP

A

g. stimulant

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5
Q

hexamethonium(C6)

A

ganglionic antagonist

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6
Q

trimethaphan

A

g. antagonist

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7
Q

mecamylamine

A

ganglionic antagonist

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8
Q

where are M1

A

in cerbral cortex
hippocampus
striatum
gastric and salivary glands

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9
Q

what do M1 do

A

increase cognitive functioning

can also increase seizures

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10
Q

where are M2

A

on the heart

smooth muscle

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11
Q

what does M2 do?

A
  • inhibit adenylyl cyclase,
  • decreases cyclic AMP
  • inhibits voltage gated calcium channels
  • increases tremors and hypothermia
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12
Q

what are M3 for

A

smooth muscles and glands

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13
Q

what do M3 do

A

increases EPSP
activates and depolarizes
increases secretion in glands and contraction of SM

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14
Q

what are M4 for

A

forebrain

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15
Q

what do M4 do

A

decreases cyclic AMP

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16
Q

ACH

A

muscarinic agonist

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17
Q

methacoline

A

m. agonist

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18
Q

carbachol

A

m. agonist

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19
Q

bethanechol

A

m. agaonist

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20
Q

arecoline

A

m. agonist

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21
Q

pilocarpine

A

m. agonist

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22
Q

muscarine

A

m. agonist

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23
Q

tacrine

A

ACHEI

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24
Q

galantamine

A

ACHEI

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25
Q

donepezil

A

ACHEI

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26
Q

edrophonium

A

ACHEI

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27
Q

rivastigmine

A

ACHEI

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28
Q

pyridostigmine

A

ACHEI

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29
Q

neostigmine

A

ACHEI

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30
Q

physostigmine

A

ACHEI

31
Q

atropine

A

muscarinic antagonist

32
Q

scoplamine

A

m. antagonist

33
Q

itomatropine

A

m. antagonist

34
Q

pirenzepine

A

m. antagonist

35
Q

ipratropium

A

m. antagonist

36
Q

tiotropium

A

m. antagonist

37
Q

tolterodine

A

m. antagonist

38
Q

where do catecholamines have hydroxyl groups

A

3rd and 4th position

39
Q

what enzyme in catecholamine synthesis needs copper ad ascorbate to work?

A

dopamine-b-hydroxylase

40
Q

what is the rate limiting enzyme in catecholamine synthesis

A

TH

41
Q

what does MAO do?

A

inactivates neurotransmitters

42
Q

what drugs breakdown catecholamines?

A 
MAO
COMT
ADH
AD-Aldehyde Dehydrogenase
VMA-Vanillymandelic Acid
43
Q

albuterol

A

B2 agonist

44
Q

ritodoine

A

B2 agonist

45
Q

salmeterol

A

B2 agoinsit

46
Q

pirbuterol

A

B2 agonist

47
Q

where is alpha 1

A

vascular smooth muscle and liver

48
Q

where is beta 2

A

SMOOTH MUSCLE

49
Q

where is B3

A

adipose tissue

50
Q

where is B1

A

juxtaglomerular apparatus and heart

51
Q

phenoxybenzamine

A

alpha antagonist ( nonselective)

52
Q

phentolamine

A

alpha antagonist ( non selective)

53
Q

tolazoline

A

alpha antagonist ( non selective)

54
Q

yohimbine

A

alpha 2 antagonist

55
Q

“zosins”

A

alpha 1 antagonist

56
Q

indoramin

A

alpha 1 antagonist

57
Q

acebutolol

A

beta blocker

58
Q

pindolol

A

beta blocker

59
Q

bucindolol

A

alpha and beta blocker

60
Q

labetolol

A

alpha and beta blocker

61
Q

carvedilol

A

alpha and beta blocker

62
Q

celiprolol

A

b2 partial AGONIST and beta 1 blocker

63
Q

droxidopa?

A

this is a precursor for epinephrine and norepinephrine, treats orthostatic hypotension

64
Q

orthostatic hypotension

A

this is when the blood pressure falls when you stand up quickly

65
Q

methylxanthines

A

adrenergic stimulant, increases cAMP

66
Q

cocaine

A

adrenergic stimulant, blocks the repute of cats

67
Q

amphetamines

A

adrenergic stimulant, causes the release of NE

68
Q

vesmacol

A

blocks the storage of Ach

69
Q

hemicholinum

A

blocks the synthesis of Ach

70
Q

dopamine

A

can vasodialate the renal arteries

71
Q

metyrosine

A

blocks NE synthesis

72
Q

reserpine

A

blocks catecholamine storage

73
Q

gunaethidine

A

blocks catecholamine release

74
Q

what drug will help parkinson patients by decreasing sweeting, rigidity, and salivation

A

atropine

Pharmacology (4 decks)

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