Autonomic Drugs Flashcards

1
Q

Nicotine

A

ganglionic stimulant

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2
Q

lobeline

A

g. stimulant

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3
Q

tetramethyl ammonium TTMA)

A

g. stimulant

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4
Q

DMPP

A

g. stimulant

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5
Q

hexamethonium(C6)

A

ganglionic antagonist

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6
Q

trimethaphan

A

g. antagonist

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7
Q

mecamylamine

A

ganglionic antagonist

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8
Q

where are M1

A

in cerbral cortex
hippocampus
striatum
gastric and salivary glands

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9
Q

what do M1 do

A

increase cognitive functioning

can also increase seizures

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10
Q

where are M2

A

on the heart

smooth muscle

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11
Q

what does M2 do?

A
  • inhibit adenylyl cyclase,
  • decreases cyclic AMP
  • inhibits voltage gated calcium channels
  • increases tremors and hypothermia
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12
Q

what are M3 for

A

smooth muscles and glands

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13
Q

what do M3 do

A

increases EPSP
activates and depolarizes
increases secretion in glands and contraction of SM

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14
Q

what are M4 for

A

forebrain

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15
Q

what do M4 do

A

decreases cyclic AMP

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16
Q

ACH

A

muscarinic agonist

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17
Q

methacoline

A

m. agonist

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18
Q

carbachol

A

m. agonist

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19
Q

bethanechol

A

m. agaonist

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20
Q

arecoline

A

m. agonist

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21
Q

pilocarpine

A

m. agonist

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22
Q

muscarine

A

m. agonist

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23
Q

tacrine

A

ACHEI

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24
Q

galantamine

A

ACHEI

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25
donepezil
ACHEI
26
edrophonium
ACHEI
27
rivastigmine
ACHEI
28
pyridostigmine
ACHEI
29
neostigmine
ACHEI
30
physostigmine
ACHEI
31
atropine
muscarinic antagonist
32
scoplamine
m. antagonist
33
itomatropine
m. antagonist
34
pirenzepine
m. antagonist
35
ipratropium
m. antagonist
36
tiotropium
m. antagonist
37
tolterodine
m. antagonist
38
where do catecholamines have hydroxyl groups
3rd and 4th position
39
what enzyme in catecholamine synthesis needs copper ad ascorbate to work?
dopamine-b-hydroxylase
40
what is the rate limiting enzyme in catecholamine synthesis
TH
41
what does MAO do?
inactivates neurotransmitters
42
what drugs breakdown catecholamines?
``` MAO COMT ADH AD-Aldehyde Dehydrogenase VMA-Vanillymandelic Acid ```
43
albuterol
B2 agonist
44
ritodoine
B2 agonist
45
salmeterol
B2 agoinsit
46
pirbuterol
B2 agonist
47
where is alpha 1
vascular smooth muscle and liver
48
where is beta 2
SMOOTH MUSCLE
49
where is B3
adipose tissue
50
where is B1
juxtaglomerular apparatus and heart
51
phenoxybenzamine
alpha antagonist ( nonselective)
52
phentolamine
alpha antagonist ( non selective)
53
tolazoline
alpha antagonist ( non selective)
54
yohimbine
alpha 2 antagonist
55
"zosins"
alpha 1 antagonist
56
indoramin
alpha 1 antagonist
57
acebutolol
beta blocker
58
pindolol
beta blocker
59
bucindolol
alpha and beta blocker
60
labetolol
alpha and beta blocker
61
carvedilol
alpha and beta blocker
62
celiprolol
b2 partial AGONIST and beta 1 blocker
63
droxidopa?
this is a precursor for epinephrine and norepinephrine, treats orthostatic hypotension
64
orthostatic hypotension
this is when the blood pressure falls when you stand up quickly
65
methylxanthines
adrenergic stimulant, increases cAMP
66
cocaine
adrenergic stimulant, blocks the repute of cats
67
amphetamines
adrenergic stimulant, causes the release of NE
68
vesmacol
blocks the storage of Ach
69
hemicholinum
blocks the synthesis of Ach
70
dopamine
can vasodialate the renal arteries
71
metyrosine
blocks NE synthesis
72
reserpine
blocks catecholamine storage
73
gunaethidine
blocks catecholamine release
74
what drug will help parkinson patients by decreasing sweeting, rigidity, and salivation
atropine