CNS stimulants Flashcards
what is methylxanthines in
caffeine and cocoa
what are the three methylxanthines
- theophylline
- amniophylline
- theobromine
what are theophylline and amniophyyline used for
bronchodialation
what methylxanthine is found in chocolate
theobromine
what are the two purinergic receptors
P1 and P2
P2X is a
ionotropic receptor that binds adenosine and ATP
P2Y is a
metabotropic receptor that binds various things like ADP, ATP UDP, UTP
wat are some important actions of methylxanthines
- bronchodilation
- weak diuretic
stimulation of gastric acid - increase beta receptor to catecholamines
what should methylxanthines not be given with and why
Beta agonist, because they already stimulate the sensitivity to catecholamines
UDE of methylxanthines?
headache, abrupt vasodilation with withdrawal
what are the 3 indications for methylxanthines
ASthma
COPD
Apnea
what easily crosses the BBB
nicotine
wat is the partial agonist that is used to quite smoking
Varenicline
chronic use of what depletes dopamine and can cause depression
cocaine
what kind of agents are amphetamines
indirect sympathomimetic agents
D isomer of amphetamines is more potent then what
L-isomer
what drug was used to loose weight in the 60
amphetamines