CNS stimulants Flashcards

1
Q

what is methylxanthines in

A

caffeine and cocoa

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2
Q

what are the three methylxanthines

A
  • theophylline
  • amniophylline
  • theobromine
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3
Q

what are theophylline and amniophyyline used for

A

bronchodialation

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4
Q

what methylxanthine is found in chocolate

A

theobromine

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5
Q

what are the two purinergic receptors

A

P1 and P2

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6
Q

P2X is a

A

ionotropic receptor that binds adenosine and ATP

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7
Q

P2Y is a

A

metabotropic receptor that binds various things like ADP, ATP UDP, UTP

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8
Q

wat are some important actions of methylxanthines

A
  • bronchodilation
  • weak diuretic
    stimulation of gastric acid
  • increase beta receptor to catecholamines
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9
Q

what should methylxanthines not be given with and why

A

Beta agonist, because they already stimulate the sensitivity to catecholamines

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10
Q

UDE of methylxanthines?

A

headache, abrupt vasodilation with withdrawal

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11
Q

what are the 3 indications for methylxanthines

A

ASthma
COPD
Apnea

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12
Q

what easily crosses the BBB

A

nicotine

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13
Q

wat is the partial agonist that is used to quite smoking

A

Varenicline

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14
Q

chronic use of what depletes dopamine and can cause depression

A

cocaine

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15
Q

what kind of agents are amphetamines

A

indirect sympathomimetic agents

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16
Q

D isomer of amphetamines is more potent then what

A

L-isomer

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17
Q

what drug was used to loose weight in the 60

A

amphetamines

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18
Q

amphetamines are used to treat what

A

ADD/ADHD and Narcolepsy

19
Q

the excretion of amphetamines can be increased by what

A

ammonium chloride

20
Q

what is methylphenidate?

A

Ridelin, used for ADD/ADHD and narcolepsy

21
Q

what are the two analeptics

A

Modafinil and Armodafinil

22
Q

what are analeptics used to treat

A

ADD/ADHD and narcolepsy ( safest)

23
Q

what are the UDE of Analeptics

A

Erythema Multiforme

Steven-Johnson Syndrome and Toxic Epidermal Necrolysis

24
Q

what Analeptic is given to infants to stimulate the rest. center when they are premature

25
what are the indications for Droxidopa
- Neurogenic Orthostatic Hypotension - Parkinsons -
26
Droxidopa is a precursor for what
NE and Epinephrine
27
true psychedelics make their effects through what
serotonin receptors
28
Theogens?
hallucinogens that are used for religious reasons
29
Lysergic Acid Diethylamide
LSD
30
Psilocybin
Shrooms
31
Mescaline
Payodee Cacti
32
DMT
Ectasy
33
Ayahuasca
native american tea with Mao inhibitors and go on long trip
34
what receptors do LSD stimualte
5HT1 and 5HT2
35
Psilocybin only reacts on what receptor?
serotonergic receptor
36
UDE of LSD
nasuea and vomiting ( 5HT receptor in the brain and stomach)
37
what is the name of a drug that can block Hallucinogenic effects
Haloperidol
38
what are some affects f THC
decreased pain and altered time perception
39
what THC is used to increases appetite and decrease pain
Dronabinol (HIV and cancer)
40
what THC antagonist is used for weight loss
Rimonabant
41
endocannabinoids CB1 are found where, CB@?
CB1- CNS | CB2-immune system
42
what is the indication for nausea and vomiting treatment
cannabinoids
43
what drug is related to ketamine and is disscociative
PCP
44
what drug creates and altered sense of time and sexual arousal
MDMA