CNS stimulants Flashcards

1
Q

what is methylxanthines in

A

caffeine and cocoa

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2
Q

what are the three methylxanthines

A
  • theophylline
  • amniophylline
  • theobromine
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3
Q

what are theophylline and amniophyyline used for

A

bronchodialation

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4
Q

what methylxanthine is found in chocolate

A

theobromine

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5
Q

what are the two purinergic receptors

A

P1 and P2

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6
Q

P2X is a

A

ionotropic receptor that binds adenosine and ATP

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7
Q

P2Y is a

A

metabotropic receptor that binds various things like ADP, ATP UDP, UTP

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8
Q

wat are some important actions of methylxanthines

A
  • bronchodilation
  • weak diuretic
    stimulation of gastric acid
  • increase beta receptor to catecholamines
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9
Q

what should methylxanthines not be given with and why

A

Beta agonist, because they already stimulate the sensitivity to catecholamines

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10
Q

UDE of methylxanthines?

A

headache, abrupt vasodilation with withdrawal

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11
Q

what are the 3 indications for methylxanthines

A

ASthma
COPD
Apnea

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12
Q

what easily crosses the BBB

A

nicotine

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13
Q

wat is the partial agonist that is used to quite smoking

A

Varenicline

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14
Q

chronic use of what depletes dopamine and can cause depression

A

cocaine

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15
Q

what kind of agents are amphetamines

A

indirect sympathomimetic agents

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16
Q

D isomer of amphetamines is more potent then what

A

L-isomer

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17
Q

what drug was used to loose weight in the 60

A

amphetamines

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18
Q

amphetamines are used to treat what

A

ADD/ADHD and Narcolepsy

19
Q

the excretion of amphetamines can be increased by what

A

ammonium chloride

20
Q

what is methylphenidate?

A

Ridelin, used for ADD/ADHD and narcolepsy

21
Q

what are the two analeptics

A

Modafinil and Armodafinil

22
Q

what are analeptics used to treat

A

ADD/ADHD and narcolepsy ( safest)

23
Q

what are the UDE of Analeptics

A

Erythema Multiforme

Steven-Johnson Syndrome and Toxic Epidermal Necrolysis

24
Q

what Analeptic is given to infants to stimulate the rest. center when they are premature

A

Doxapram

25
Q

what are the indications for Droxidopa

A
  • Neurogenic Orthostatic Hypotension
  • ## Parkinsons
26
Q

Droxidopa is a precursor for what

A

NE and Epinephrine

27
Q

true psychedelics make their effects through what

A

serotonin receptors

28
Q

Theogens?

A

hallucinogens that are used for religious reasons

29
Q

Lysergic Acid Diethylamide

A

LSD

30
Q

Psilocybin

A

Shrooms

31
Q

Mescaline

A

Payodee Cacti

32
Q

DMT

A

Ectasy

33
Q

Ayahuasca

A

native american tea with Mao inhibitors and go on long trip

34
Q

what receptors do LSD stimualte

A

5HT1 and 5HT2

35
Q

Psilocybin only reacts on what receptor?

A

serotonergic receptor

36
Q

UDE of LSD

A

nasuea and vomiting ( 5HT receptor in the brain and stomach)

37
Q

what is the name of a drug that can block Hallucinogenic effects

A

Haloperidol

38
Q

what are some affects f THC

A

decreased pain and altered time perception

39
Q

what THC is used to increases appetite and decrease pain

A

Dronabinol (HIV and cancer)

40
Q

what THC antagonist is used for weight loss

A

Rimonabant

41
Q

endocannabinoids CB1 are found where, CB@?

A

CB1- CNS

CB2-immune system

42
Q

what is the indication for nausea and vomiting treatment

A

cannabinoids

43
Q

what drug is related to ketamine and is disscociative

A

PCP

44
Q

what drug creates and altered sense of time and sexual arousal

A

MDMA