Serotonin

Question 1

Serotonin takes place in two reactions

Answer 1

1st hydroxylation catalyzed by TRP hudroxylase then

2nd decarboxylation by L-amino acid decarboxylase

Question 2

Serotonin to 5-hydroxy indole acetic acid, catalyzed by what and what reaction?

Answer 2

MAO - oxidative deamination

Question 3

Serotonin targets?

Answer 3

Sert rors: 5HT 1,2,3 (migraine, n&v)
sert reuptake (antidepressants)
breakdown of sert by MAO (antidepressants)

Question 4

Deficiency of rors 5HT 1,2,3

Answer 4

Anxiety depression aggression impulsive and appetite

Question 5

What 5HT ror in CNS acts as NT for anti anxiety, antidepressant anti aggressive, antiemetic.

Answer 5

5HT1a -Buspirone

Question 6

5HT agonist that causes CNS vc.

Answer 6

5HT1b/1d: Triptan for migraine attacks

Sumatriptan, Riza, Zolmi, Frova, Almo

Question 7

5HT2 non selective agonist for acute migraine drugs and clinical significance.

Answer 7

Ergotamine and Cyproheptadine.
Platelets, sm musc, (5HT constricts sm of bronchi and GI) CNS -ve schizo symptom
Cypro -both 5HT 1,2 to increase appetite

Question 8

5HT antagonists for CNS, GI- acts as local hormone and to regulate peristalsis movement

Answer 8

5HT3 antagonists -setrons
Antiemetic in chemotherapy
Ondansetron, Alosetron etc

Question 9

Ondansetron and Granisetron chemical struc. and SEs

Answer 9

Ondansetron (indole) Constipation HE dizziness

Granisetron (benzimidazole) diarrhea

Question 10

5HT4 agonist receptors and drugs.

Answer 10

Ergotamine serotonin partial ant/agonist:
Cisaperide (benzamide)
Tagaseride (indole)

Question 11

Other Ergot alkaloids partial ant/agonists.

Answer 11

Ergonovine, Dyhydroergotamine (DHE), Methysergide and Bromocriptine

Question 12

MOA of Triptans, ror and chemical structure.

Answer 12

5HT1b/1d agonists: all are indole deriv

MOA: contraction of arterial smooth muscles, especially in carotid and cranial circulations.