Serotonin

Question 1

5-HT2A

Answer 1

Platelets

Question 2

What does serotonin do to healthy vs unhealthy vessels

Answer 2

Healthy: vasodilation
Unhealthy: vasoconstriction

Question 3

Where is 80% of serotonin?

Answer 3

In enterochromaffin cells in the GI tract

Question 4

5-HT1b

Answer 4

Gi tracT: Secretory and peristaltic reflexes

Question 5

How is serotonin synthesized?

Answer 5

Tryptophan—>TPH (tryptophan hydroxylase, RLS)–>eventually get to 5HT

Question 6

SERT

Answer 6

Presynaptic transporter that removes 5HT from cleft

S allele for SERT leads to inc depression

Question 7

VMAT

Answer 7

Vesicular monoamine transporter transports 5HT from cytoplasm into vesicle to protect it from MAO breakdown

Question 8

Fenfluramine MOA

Answer 8

Inhibits SERT and VMAT

Question 9

Serotonin Syndrome

Answer 9

Abdominal pain, diarrhea, sweating, fever, tachycardia, increased BP, altered mental stae

Question 10

What disease is associated with 5HT1A

Answer 10

GAD (increased GABA)

Question 11

What disease is associated with 5HT 1D/1F

Answer 11

Migraine (reduce neuroinflammation and vasoconstrict and inhibit CGRP relase)

Question 12

How do we think SSRIs work

Answer 12

Increase serotonin, increased CREB, increased BDNF, increased hippocampal neurogenesis