serotinin (5-HT) crash course Flashcards
1
Q
distribution of 5HT?
A
wall of intestine (ECF cells),
blood (platelets have high affinity for 5HT, ccumulating from the plasma in a active transport) and the CNS
2
Q
what are the 2 ergot alkaloids
A
ergotamine and methysergide
3
Q
what receptor does ergotamine act one
A
5-HT1 and alpha adrenoreceptors
4
Q
what receptor does methysergide act on
A
5-HT2A
5
Q
what’s impt about methysergide?
A
migraine prophylaxis and treatment of carcinoid symptoms