serotinin (5-HT) crash course Flashcards

1
Q

distribution of 5HT?

A

wall of intestine (ECF cells),
blood (platelets have high affinity for 5HT, ccumulating from the plasma in a active transport) and the CNS

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2
Q

what are the 2 ergot alkaloids

A

ergotamine and methysergide

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3
Q

what receptor does ergotamine act one

A

5-HT1 and alpha adrenoreceptors

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4
Q

what receptor does methysergide act on

A

5-HT2A

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5
Q

what’s impt about methysergide?

A

migraine prophylaxis and treatment of carcinoid symptoms

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