Seronegative Spondyloarthropathies

Question 1

Gene associated with these:

Answer 1

HLA-B27

Question 2

Distinguishing Features of them all:

Answer 2

Inflammation of Axial Joints
Enthesitis
Dactylitis

Question 3

Ankylosing Spondylitis:

Answer 3

• Fibrous or bony bridging of joints in the spine (Bamboo Spine)
• Increased risk of Aortic regurgitation
• Patient will be hunched over as it progresses

Question 4

Reactive Arthritis/Reiter’s Syndrome:

Answer 4

• Acute non-purulent arthritis as a complication of an infection elsewhere in the body
• CLASSIC TRIAD: Conjunctivitis, Urethritis and Arthritis
• Keratoderma blennorrhagica on palms and soles
• Dactylitis
• Need to differentiate ReA from DGI

Question 5

Psoriatic Arthritis:

Answer 5

• Inflammatory MSK disease w/ autoimmune and autoinflammatory features
• Psoriasis precedes joint disease
• Involves the DIP joints
• Dactylitis, Enthesitis of Achilles tendon, Severe nail dystrophy, Discoid plaques on skin

Question 6

Enteropathic Arthritis:

Answer 6

• Relationship with IBM, Crohn’s and Ulcerative Colitis

- Trafficking of leukocytes between gut and the joint