Seretonin and Dopamine Drugs Flashcards
5-HTP
seretonin precursor for depression
Buspirone
5HT1A agonist at the cortex
Indication: anxiety, (depression off label)
Side Effects: anxiety, drowsiness, nausea
Sumatriptan
5HT1D agonist for migraines
MEch: inhibit inflammatory mediator release
Side Effect: coronary vasoconstriction
Risperidone
5HT2A/2C antagonist for depression, psychosis
MEch: Decrease dopamine at mesolimbic, increase dopamine at mesocortical
Indication: schizophrenia, psychosis
Side effect: weight gain, resltessness (akithesia)
Odansetron
5HT3 to trat chemo induced emesis with no side effects
Fluoxetine
5HT1A SSRI- block reuptake to increase
Indication: depression, OCD, anxiety, PTSD, social phobia
Side Effect: sexual dysfunction, insomnia
CI: MAO inhibitors- lead to seretonin syndrome
Sertariline
5HT1A SSRI- block reuptake to increase
Indication: depression, OCD, anxiety, PTSD, social phobia
Side Effect: sexual dysfunction, insomnia
CI: MAO inhibitors- lead to seretonin syndrome
L-DOPA
Dopamine orecursor for parkinson’s
Side effects = arrythmis, dyskanesia
Bromocriptine
D2 agonist in parkinsons
Carbidopa
aromatic acid decarboxylase inhibitor for parkinsons
Selegiline
MAO-B inhibitor in parkinsons
Talcapone
COMT Inhibitor in parkinsons
MEthylphenidate
Dopamine reuptake inhibitor for ADHD
Side effect= tachycardia
MEtaclopramide
D2 agonist for neausea
Side effect = akathesia
Haloperidol
D2 agonist for psychosis
Side effect: extra-pyramidal motor disturbances
