Neuromuscular Relaxants Flashcards
Succinylcholine
Neuromuscular Depolarizing Agent
Indication: tracheal intubation or Electo-therapy
Duration- 15-20 minutes
Excretion- Plasma cholinesterase
Pancuronium
Neuromuscular Non-depolarizing agent
Indication: anestesia adjuvant, ab wall relaxation, ortho
Duration: 30-60 minutes
Excretion: Renal
D-tubocurarine
Non-depolarizing
Prototype- not used
60 min and more duration
Liver/renal clearance
Rocuronium
Neuromuscular Non-depolarizing agent
Indication: intubation, surgery, ventilation
Duration- 25 minutes
Excretion: Liver
Mivacurium
NM Non-depolarizing agent
Indication: Intubation, surgery, vent in liver failure
Duration: 15 minutes
Excretion- plasma cholinesterase
Vecuronium
NM non-depolarizing
Indication: surgical anesthesia, ab wall, ortho
Duration: 30-45 minutes
Excretion: liver, ranal
Baclofen
Spasmolytic drug
Indication: muscle spasticity with MS, SC injury
Mechanism: Inhibit NT release from muscle to sensory by GABAb and decreasing calcium in 1a afferent
Side Effect: drowsiness
Diazepam
Spasmolytic drug
Indication: muscle spasm from injury, loss of inhibition
MEchanism: benzodiazepine agonist by GABAa and chlorine in
Side Effect: drowsiness, sedation
Tizanidine
Spasmolytic
Indication: spasticity due to MS, SC injury
Mechanism: alpha-2 agonist in CNS
Side effect: drowsiness, hypotension
Dantrolene
Spasmolytic
Indication: muscle spasm, malignant hyperthermia
Mechanism- ryanodine receptor blocker
Side Effect: weakness, sedation, liver inflammation
Classes of NM Relaxants
Depolarizing, non-depolarizing, spasmolytic
Non-depolarizing agents
Pancuronium, Tubocurarine, Rocuronium, Mivacarium, Vecorunium
Depolarizing Agents
Succinylcholine
Spasmolytic Agents
Baclofen, Diazepam, Tizanidine, Dantrolene
