SEPSIS

Question 1

What does tissue damage or bacteria cause?

Answer 1

Activation of inlammatory mediators

Question 2

Inflammatory response Vasodilation

Answer 2

Vasodilation - want as many WBC around that area as possible / floods with Oxygen/Glucose/WBC
Redness

Question 3

Inflammatory response capillary permeability

Answer 3

Capillary Permeability - You want the WBC out of the vascular and into the tissue to fight it! Want glucose and oxygen out of vasculature and into the tissue for nutrients and healing! Swelling

Question 4

Inflammatory response increased coagulation

Answer 4

Controlled bleeding

Question 5

When mediators (swelling, redness) are local you call that an

Answer 5

infection

Question 6

If bacteria crosses the vascular membrane

Answer 6

SIRS

Question 7

Bacteria now in the blood

Answer 7

SEPSIS

Question 8

the 3 inflammatory response become what in sepsis?

Answer 8

SYSTEMATIC - NO LONGER LOCAL

Question 9

Sepsis bundle

WITHIN 3 HOURS OF ARRIVAL

Answer 9

1. Measure lactate
2. Blood Cultures
3. Broad spectrum abx
4. 30 ml/kg for hypotension or lactate >4

Question 10

Sepsis bundles

WITHIN 6 HOURS OF TRIAGE

Answer 10

Vasopressors

MAP 65 or above

Question 11

SIRS qualifications

Answer 11

T: >100.4F or <96.8
RR: >20
HR: >90
WBC: 12,000 ; 4,000 or >10% Bands
PCO2: <32mmHG

Question 12

Normal band count

Answer 12

10% or less

Question 13

What are bands WBC?

Answer 13

Immature form of a neutrophil
Essential for fighting disease
Produced in excess during infection

Question 14

SEPSIS Qualification

Answer 14

2 SIRS

+

Confirmed or suspected infection

Question 15

Severe Sepsis

Answer 15

Sepsis + Signs of EOF + Hypotension <90 + Lactate >2

Question 16

Septic Shock

Answer 16

Severe sepsis + Persistent Hypotension in the hour after 30ml/kg bolus + Lactic >4