Anaphylaxis Flashcards
How is it similar to sepsis?
Mediator release
How is it difference than sepsis?
Antigen exposure –> mediator release
Initial S/S
Hives (from capital permeability from the skin)
Flushing (vasodilation)
Tachycardia
Vasodilation causes
Hypotension
Mucosal edema/airway (most vasodilation is in upper airway)
Obstruction
Capillary permeability causes
Hypovolemia
Pulmonary Congestion
3 Drugs of choice
Bronchodilator (Inhaled Beta - 2 agonists)
Corticosteroids (suppresses inflammatory - prevent delayed reaction)
Antihistamine
H1 Blocker
Benadryl
H2 Blocker
Cimetindine, Ranitdaine, Famotidine
Mild anaphylaxis characterized by
Normal BP
Minimal RD
Mild anaphylaxis dosage of EPI
IM 1:1,000
Severe Anaphylaxis characterized by
Hypotension
Severe RD
Severe anaphylaxis dosage of EPI
IV 1:10,000
Repeat 15-30 mins PRN up to 2 doses
What can BB inhibit?
The work of EPI in anaphylaxis
What can a BB do to the lungs?
Vasoconstriction
Bronchospams
EPI has both..
Alpha-Adrenergic (Vasoconstriciton)
Beta-Adrenergic (Vasodilation)