Sepsis

Question 1

Continuum of blood infection:

Answer 1

Bacteremia
SIRS
Sepsis
Severe Sepsis
Septic Shock
MODS

Question 2

SIRS criteria two or more of the following:

Answer 2

1. ) Fever or Hypothermia
2. ) Tachycardia
3. ) Tachypnea or Hypocapnia
4. ) Leucocytosis or leucopenia or left shift of immature neutrophils

Question 3

Sepsis criteria:

Answer 3

1. ) Must meet SIRS criteria

2. ) Suspected or Documented infection somewhere in/on the body

Question 4

Severe Sepsis criteria:

Answer 4

1. ) Must meet criteria for Sepsis
2. ) Dysfunction of one organ system
3. ) Decreased tissue perfusion
4. ) Hypotension

Question 5

Septic shock criteria:

Answer 5

1. ) Severe sepsis
2. ) Hypotension despite fluid resuscitation
3. ) Decreased tissue perfusion

Question 6

Most predictive biomarker decrease in MODS, what induces this decrease?

Answer 6

HLA-DR (Class II)

Cortisol and IL-10 (inactivate macrophages)

Question 7

Four types of shock:

Answer 7

Hypovolemic
Cardiogenic
Distributive (septic)
Obstructive

Question 8

Sepsis Therapy:

Answer 8

1. ) Normalize Preload (IVF)
2. ) Maintain perfusion pressure (Vasoconstrictors/NE)
3. ) Optimize O2 delivery
4. ) Antibiotics early