Neoplastic Endocrinopathy and Paraneoplastic Syndrome

Question 1

Ectopic parathyroid hormone:

Answer 1

Squamous cell
GI
GU

Question 2

Ectopic 1,25 Dihydroxyvitamin D:

Answer 2

Lymphomas

Question 3

Ectopic ADH (SIADH):

Answer 3

Lung (squamous and small cell)
Ovary
GU/GI

Question 4

Ectopic ACTH (Cushing’s Syndrome):

Answer 4

Lung
Thymus
pNET
Medullary thyroid carcinoma

Question 5

Carcinoid Syndrome causing tumors:

Answer 5

Carcinoid lung
pNET
GI net

Question 6

Paraneoplastic Antibodies:

Answer 6

Cell surface: PNS or NMJ
Cell surface: CNS
Intracellular: CNS

Question 7

Myasthenia gravis Ab and cancer associated:

Answer 7

Ab: acetylcholine receptor
Cancer: Thymoma

Question 8

Lambert Eaton Ab and cancer associated:

Answer 8

Ab: VGCC
Cancer: small cell lung

Question 9

Autonomic neuropathy Ab and associated cancer:

Answer 9

Ab: ACR
Cancer: Thymoma

Question 10

Encephalitis w/ psychosis surface Ab and cancer:

Answer 10

Anti-NMDA-NR1

Ovarian teratoma

Question 11

Limbic encephalitis surface Ab and cancer:

Answer 11

Anti-AMPA-GluR-3

Small Cell Lung or Hodgkin

Question 12

Cerebellar degeneration surface Ab and cancer:

Answer 12

Anti-mGluR1

Hodgkin’s or prostate

Question 13

Stiff person syndrome surface Ab and cancer:

Answer 13

Glycine receptor

Hodgkin’s

Question 14

Cerebellar degeneration intracellular Ab and cancer:

Answer 14

Multiple neuronal; Anti-Ri

Lung/Breast

Question 15

Limbic encephalitis intracellular Ab and cancer:

Answer 15

Anti-MA

Men: germ cell tumors

Question 16

Stiff person syndrome intracellular Ab and cancer:

Answer 16

Amphiphysin

Ovarian/breast

Question 17

Demyelinating polyneuropathy Ab and cancer:

Answer 17

MAB w/ gamma light chain

Waldenstrom’s macroglobulinemia IgM MAB

Question 18

POEMS antibody and tumor:

Answer 18

Monoclonal Abs

Osteosclerotic Myeloma

Question 19

POEMS clinical syndrome symptoms:

Answer 19

Polyneuropathy
Organomegaly
Endocrinopathy
Monoclonal Ab
Skin changes