Pharmacology

Question 1

What are alkylating agents used for?

Answer 1

Leukemia and lymphoma

Question 2

What are traditional alkylating agents used for?

Answer 2

Lymphoid and myeloid tumors

Question 3

What drug causes hemorrhagic cystitis?

Answer 3

Cyclophosphamide

Question 4

What reduces Cyclophosphamide toxicity?

Answer 4

MESNA

Question 5

What are good CNS penetrating drugs?

Answer 5

Carmustine

Iomustine

Question 6

What are Carmustine/Iomustine used to treat?

Answer 6

Brain tumor

Leukemia

Question 7

What are non classical alkylating agents used to treat?

Answer 7

Leukemia

Lymphoma

Question 8

What are platinum analogs used for?

Answer 8

Solid tumors

Question 9

What are antimetabolites used for?

Answer 9

All tumors

Question 10

What causes Hand Foot syndrome?

Answer 10

5-FU

Question 11

What is Cytarabine used for?

Answer 11

Soft tissue tumors

Question 12

What class of drugs has major interactions when given with allopurinol?

Answer 12

Purine antagonists

Question 13

What are purine antagonists used to treat?

Answer 13

Lymphoid and myeloid tumors

Question 14

What are taxanes used for?

Answer 14

Solid tumors

Question 15

What is the least bone marrow suppressing cancer drug?

Answer 15

Vincristine

Question 16

Treatment limiting vinca and taxane side effects:

Answer 16

Peripheral and autonomic neuropathy

Question 17

Bleomycin life time limiting dose side effect

Answer 17

Pulmonary toxicity

Question 18

Inhibits phosphorylation and translocation to form philadelphia chromosome:

Answer 18

Imatinib

Question 19

Philly chromosome is linked to what cancer?

Answer 19

CML

Question 20

Used as anti-VEGFR for metasteses?

Answer 20

Bevacizumab

Question 21

Used for anti epidermal growth factor receptor:

Answer 21

Cetuximab

Question 22

Used in all HER-2 positive cancers:

Answer 22

Trastuzumab

Question 23

Destroys all CD20 positive B cells:

Answer 23

Rituximab