Sensory systems: Hearing Flashcards

1
Q
A
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2
Q

What can the auditory pathway be overall divided into?

A

Outer ear, middle ear, inner ear

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3
Q

What is the outer ear and what is it made up of?

A

The outer ear is the most outer part of the auditory pathway. It consists of the pinna (ear lobe), the auditory canal, and the tympanic membrane.

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4
Q

What is the middle ear made up of and what is its role?

A

The middle ear is a cavity that contains 3 little bones: malleus, incus, and stapes. These bones connect the tympanic membrane to the inner ear.

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5
Q

What is the middle ear connected to and via what?

A

The middle ear has a connection to the nasal cavity via the eustachian tube.

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6
Q

What is the inner ear made up of and what are its roles?

A

The inner ear includes the cochlea, which is responsible for hearing, and the semi-lunar canal, which relates to vestibular functions (balance).

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7
Q

What is the role of the little bones in the ear?

A

They work as a lever system to transmit sound waves from the tympanic membrane to the oval window of the inner ear and amplify sound (about 20x) for low intensity sounds.

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8
Q

What is the mechanism to reduce amplification in the ear?

A

The mechanism is provided by two muscles of the middle ear: the stapedius muscle and the tensor tympani muscle. They contract in reflex to very high intensity sounds, stopping the amplification of sound by the three bones.

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9
Q

What is the structure of the cochlea?

A

The cochlea looks like a snail and is coiled up. Uncoiled, it has three tubes: the Scala vestibuli, the Scala media, and the Scala tympani.

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10
Q

What connects and divides the Scala tympani and vestibuli?

A

They are connected at the apex of the coil via a hole called the Helicotrema. The division is provided by the basilar membrane.

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11
Q

What does the Scala media contain?

A

The Scala media contains the organ of Corti, which is the sensory organ of hearing.

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12
Q

What is the mechanism of hearing?

A

When the sound wave hits the little bones, they move and the stapes pushes onto the membrane on the oval window, pushing the liquid in the cochlea and causing it to move.

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13
Q

What is the liquid in the cochlea called?

A

The liquid in the cochlea is called endolymph.

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14
Q

What does the movement of the endolymph cause?

A

The back-and-forth movement of the endolymph leads to deflections of the basilar membrane inside the inner ear.

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15
Q

Describe the structure of the basilar membrane.

A

The basilar membrane’s width and rigidity change along its length. It is narrow and stiff at the base, and wider and floppier at the apex.

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16
Q

What is the organ of Corti?

A

The Organ of Corti is the sensory organ of hearing found on the basilar membrane.

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17
Q

What cells are found in the organ of Corti and how does sound affect them?

A

The important sensory cells are the hair cells (outer and inner). Movement of the organ of Corti causes the tectorial membrane to move, which bends the stereocilia of the hair cells, leading to depolarization.

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18
Q

What are the action potentials (APs) elicited in hair cells linked to?

A

The APs in hair cells are linked directly to the movement of the stereocilia.

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19
Q

What allows for depolarization of hair cells?

A

Depolarization occurs due to mechanically gated K+ ion channels. Movement of stereocilia opens these channels, allowing K+ influx, leading to membrane depolarization.

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20
Q

What are auditory nerve fibers made up of?

A

Most of the auditory nerve is made up of fibers from spiral ganglion cells that innervate the inner hair cells.

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21
Q

What allows outer hair cells to contract or relax?

A

Outer hair cells have motor proteins associated with their wall that can contract or relax.

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22
Q

What happens when the motor proteins in outer hair cells contract?

A

When these motor proteins contract, they pull the stereocilia in a different direction, tugging the tectorial membrane and amplifying sound perceived by the inner hair cells.

23
Q

What two phenomena allow us to identify sounds with different frequencies?

A

Tonotopy and characteristic frequency allow us to distinguish sounds of different frequencies.

24
Q

What is tonotopy?

A

Tonotopy is the topographical organization of the auditory system.

25
What does the difference in flexibility of the basilar membrane cause?
The difference in flexibility causes the apex to move with low frequency sounds and the base to move with high frequency sounds.
26
What is tonotopy?
Tonotopy is the topographical organisation of the auditory system.
27
Describe the flexibility of the basilar membrane.
The flexibility of the Basilar membrane is different at the apex and base; the apex moves with low frequency sounds while the base is moved by high frequency sounds.
28
What does the difference in flexibility of the basilar membrane cause?
It gives a distribution of frequency response along the length of the membrane, leading to tonotopy.
29
What maintains the topographical organisation of the auditory system?
The topographical organisation is maintained at higher levels of the auditory pathways, such as the Cochlear nucleus.
30
What is characteristic frequency?
Characteristic frequency is the frequency to which inner hair cells respond best, with maximal response at that frequency.
31
What is the function of the auditory cortex?
The auditory cortex has a preserved tonotopy, allowing for the identification of different frequencies.
32
What is phase locking?
Phase locking is a phenomenon where action potentials are elicited by each cycle of a low frequency sound wave.
33
How do we identify very low frequency sounds?
Frequency identification for very low frequencies is based on phase locking.
34
How do we identify intermediate frequency sounds?
Intermediate frequencies are identified using both phase locking and tonotopy.
35
How is high frequency sound located?
High frequency sounds rely entirely on tonotopy as phase locking is not possible.
36
What does sound intensity perception depend on?
Sound intensity perception depends on the number of inner hair cells firing and their firing rate.
37
Why does losing hearing in one ear not affect hearing too much?
Losing hearing in one ear does not significantly affect hearing because messages from the other ear still reach both sides of the auditory cortex.
38
What is sound localisation?
Sound localisation is the ability to determine the direction of a sound based on interaural delay and intensity differences.
39
What happens if you lose hearing in one ear?
You will be unable to localise sound but can still hear and identify the frequency.
40
What is conduction deafness?
Conduction deafness is caused by any obstruction in the path of air waves.
41
What can lead to nerve deafness?
Any damage to the inner ear or the ascending auditory pathways can lead to nerve deafness.
42
What is presbycusis?
Presbycusis is a normal progressive age-related loss of hearing acuity or sensitivity.
43
What are some causes of acquired nerve deafness?
Acquired nerve deafness can be caused by noise, diseases, inflammatory conditions, and trauma.
44
What are the types of damage?
Damage can be permanent or temporary, and can be environmental or occupational noise damage, or acoustic trauma (explosion near you).
45
What diseases can cause acquired nerve deafness?
Diseases include inflammatory conditions, diabetes mellitus, iodine deficiency/hypothyroidism, tumours, meningitis, viral infections (AIDS, Mumps, Measles, herpes zoster oticus), trauma, and stroke.
46
What are ototoxic and neurotoxic drugs?
These are drugs that can lead to hearing loss.
47
What are the groups of ototoxic drugs?
Groups include aminoglycosides (antibiotics) which cause various degrees of hearing loss, and methotrexate which can cause irreversible hearing loss.
48
What is a rare mitochondrial mutation related to aminoglycosides?
The mutation m.1555A>G can increase susceptibility to the ototoxic effect of aminoglycosides.
49
What perinatal conditions can affect hearing?
Conditions include premature birth, foetal alcohol syndrome, and fetal syphilis.
50
What is the role of outer hair cells in hearing?
Outer hair cells contain motor proteins that amplify sound by moving the tectorial membrane.
51
What is tinnitus?
Tinnitus is the sensation of sound when there is no sound around, caused by motor proteins contracting in outer hair cells.
52
Why is tinnitus difficult to treat?
It is difficult to treat due to its complex nature.
53
What is the auditory pathway?
The auditory pathway includes the cochlear nerve, cochlear nucleus, superior olive, lateral lemniscus, inferior colliculus, medial geniculate nucleus (MGN), and auditory cortex.
54
What is the benefit of sound processing in both cerebral hemispheres?
Damage to one hemisphere does not result in complete hearing loss, allowing for more processing potential of sounds.