Higher cortical function: Memory Flashcards

1
Q

What is learning?

A

Acquisition of ‘experience’.

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2
Q

What is memory?

A

Retention of ‘experience’

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3
Q

Why is having learning and memory important?

A

Learning & memory work together to enable the individual to adapt their behaviour.

E.g. if you do something and the outcome was good, then you are more likely to repeat the activity and vice versa.

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4
Q

What is the contrast between learning and stereotypical reflexes?

A

In stereotypical reflexes, the same thing is always done – no learning, no change, no adaptation.

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5
Q

How has the development of the brain impacted responses?

A

The development of the brain has enabled us to move from fixed responses to varying responses over time and with experience.

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6
Q

How is memory classified?

A

Memory classification is done on 2 bases: the nature of the memory and duration.

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7
Q

What are the 2 types of memory based on nature?

A

Declarative and non-declarative.

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8
Q

What is declarative memory?

A

‘You can declare the information’. It is explicit, ‘the what’.

E.g. There is a chair, I know it’s a chair because it has a seat and 4 legs.

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9
Q

What happens to declarative memory over time?

A

It fades with time unless it is reused.

‘Use it or lose it’. E.g. Remembering your PIN for ATM. If you do not use it for a while, you will eventually forget it.

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10
Q

What are the types of declarative memory?

A

Semantic declarative memory and episodic declarative memory.

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11
Q

What is semantic declarative memory?

A

Memory for facts.

E.g. The Eiffel Tower is in Paris.

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12
Q

What is episodic declarative memory?

A

All about events, bringing together pieces of information to remember a particular event.

E.g. You may remember what you had for lunch on your birthday but not the day before.

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13
Q

What is non-declarative memory?

A

Implicit memory that is hard to declare, often described as skills, habits, or behaviours.

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14
Q

What are the types of non-declarative memory?

A

Procedural memory, conditioned responses, and emotional responses.

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15
Q

What is procedural memory?

A

Skills and habits.

E.g. Learning how to ride a bike.

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16
Q

What are conditioned responses?

A

Associated reflexes.

E.g. Pavlov’s dogs learned to associate the sound of a bell with food.

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17
Q

What are emotional responses in non-declarative memory?

A

Emotional responses can be shaped by our experience and change over time.

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18
Q

What are the 4 types of memory based on duration?

A

Sensory memory, short-term memory, long-term memory, and working memory.

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19
Q

What is sensory memory?

A

Lasts for fractions of a second during basic sensory processing.

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20
Q

What is short-term memory?

A

Lasts approximately 30 seconds with a limited capacity of 7 ± 2 items.

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21
Q

What is long-term memory?

A

Short-term memory converted for long-term storage through consolidation.

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22
Q

What is working memory?

A

Processing of newly acquired information combined with long-term memory.

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23
Q

What is the process of converting from short-term memory to long-term memory known as?

A

Consolidation.

24
Q

Why is forgetting necessary?

A

Forgetting helps prevent the brain from being overwhelmed by sensory information.

25
What is forgetting associated with?
Increasing age and pathological situations.
26
Why is forgetting associated with aging?
Evidence is mixed; it may relate to acquiring new information or retrieval difficulties.
27
What is thought to be causing changes in memory in the aging brain?
Loss of synapses rather than loss of neurons.
28
What is amnesia and what is it secondary to?
Amnesia is loss of memory secondary to pathology such as traumatic brain injury or neurodegeneration.
29
What is important to consider when looking at amnesia?
The location of pathology is more important than the cause.
30
What are the 2 types of amnesia?
Retrograde amnesia and anterograde amnesia.
31
What is retrograde amnesia?
Loss of memory from before the trauma, affecting declarative memory more.
32
What is Ribot’s law?
It states that recent memories are more likely to be lost than older ones.
33
Is retrograde amnesia reversible?
It may be reversible on recovery from the underlying pathology.
34
What is anterograde amnesia?
Inability to form new memories.
35
What does the existence of two types of amnesia suggest?
Different aspects of neurobiology are involved in acquiring new memories and storing information.
36
What is the current understanding of the anatomical location of memory?
Memory is based on a network of connected regions in the brain.
37
Which parts of the brain are important for declarative memory?
The medial temporal lobes.
38
Which type of memory is affected in medial temporal lobe lesions?
Episodic memory (declarative) is particularly affected.
39
Describe the anatomical pathway of declarative memory.
Sensory information passes through the medial temporal lobe structures, particularly the hippocampus, for consolidation.
40
What is Korsakoff’s syndrome?
Associated with prolonged chronic alcoholism, affecting episodic memory.
41
Which parts of the brain are important for non-declarative memory?
Cerebellum, supplementary motor area, basal ganglia, and amygdala.
42
What is the case study of HM?
He had bilateral temporal lobectomy, resulting in severe anterograde amnesia for declarative memories but intact childhood memories.
43
Which parts of the brain are important for working memory?
Involves the prefrontal cortex and other nuclei. Individuals can have problems with working memory but no problems with declarative memory and vice versa.
44
What is neuroplasticity?
The process by which neurones change their state before and after information storage.
45
What are the processes that underpin neuroplasticity?
1. Change in neurotransmission (chemical) 2. Change in synaptic structure (anatomical)
46
What do changes in neurotransmission involve?
Synaptic activity is increased (potentiated) or reduced (depressed) at particular synapses.
47
Describe long term potentiation (LTP).
LTP involves a change in the level of neurotransmission in synapses following strong stimulation, leading to an elevated response in neurones for up to 60 minutes.
48
What happens during normal stimulation at the synapse?
Presynaptic neurone releases a bit of its neurotransmitter (NT), which is glutamate in mammals, binding to AMPA receptors and causing depolarization.
49
What happens during intense stimulation at the synapse?
Both AMPA and NMDA receptors are activated, leading to changes in the post-synaptic neurone.
50
What enables LTP to take place in the synapse?
NMDA receptors allow calcium to enter the cell, leading to immediate changes in the neurone and long-term alterations in gene expression.
51
What else happens in the synapse that enables LTP?
Changes in physical structure occur, such as the formation of new synapses due to increased activity.
52
What is synaptic neuroplasticity?
Some synapses are more plastic than others, allowing for learning and memory but making them vulnerable as the brain ages.
53
How is the relation between pre- and post-synaptic neurones strengthened?
Reactivation of synapses is important for inducing neuronal plasticity; the more a synapse is used, the stronger the relation becomes.
54
How can memory be manipulated pharmacologically?
1. Enhancement of memory through nootropics. 2. Suppression of memory using NMDA antagonists like ketamine.
55
How can memory be manipulated non-pharmacologically?
Cognitive Behavioral Therapy (CBT) can reactivate synapses, changing their activity levels and potentially benefiting individuals with PTSD.