Seminar 2 - Tumour suppressor genes Flashcards
1
Q
Define a tumour suppressor gene.
A
- A gene which helps control or regulate cell growth
- A gene which protects a cell from one or more steps on the path to cancer
- A gene, which when mutated, predisposes an individual to cancer
2
Q
Outline the three classes of tumour suppressor genes.
A
- Gatekeepers: prevents the growth of potential cancer cells - classic TSGs
- Landscapers: genes that control the cellular microenvironment
- Caretakers: genes that maintain the integrity of the genome
3
Q
State the hallmarks of cancers linked to oncogenes.
A
- Resisting cell death
- Avoiding immune destruction
- Enabling replicative immortality
4
Q
State the hallmarks of cancer linked to TSGs.
A
- Activating invasion and metastasis
- Tumour-promoting inflammation
- Deregulating cellular energetics
- Sustaining proliferative signalling
- Inducing angiogenesis
- Genome instability and mutation
- Evading growth suppressors