Seminar 2 - Tumour suppressor genes Flashcards

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1
Q

Define a tumour suppressor gene.

A
  1. A gene which helps control or regulate cell growth
  2. A gene which protects a cell from one or more steps on the path to cancer
  3. A gene, which when mutated, predisposes an individual to cancer
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2
Q

Outline the three classes of tumour suppressor genes.

A
  1. Gatekeepers: prevents the growth of potential cancer cells - classic TSGs
  2. Landscapers: genes that control the cellular microenvironment
  3. Caretakers: genes that maintain the integrity of the genome
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3
Q

State the hallmarks of cancers linked to oncogenes.

A
  1. Resisting cell death
  2. Avoiding immune destruction
  3. Enabling replicative immortality
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4
Q

State the hallmarks of cancer linked to TSGs.

A
  1. Activating invasion and metastasis
  2. Tumour-promoting inflammation
  3. Deregulating cellular energetics
  4. Sustaining proliferative signalling
  5. Inducing angiogenesis
  6. Genome instability and mutation
  7. Evading growth suppressors
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