Semi-solids

Question 1

Is there a preservative in the simple eye ointment?

Answer 1

No - it’s anhydrous so doesn’t require one

Question 2

What is the main excipient in the eye ointment that may cause side effects in the patient and why?

Answer 2

Lanolin - causes sensitivity and blurring

Question 3

What are two disadvantages of using eye ointment compared to eye drops?

Answer 3

More difficult to apply as it is a thin line that needs to be applied carefully
Can cause blurred vision for a longer period of time

Question 4

What are two advantages for the patient when using this eye ointment compared to eye drops?

Answer 4

Stays in the eye for a longer period of time and works for longer
No preservative in the product so anyone with an allergy can use it

Question 5

What is the look and feel of doublebase gel compared to E45 and Bongela?

Answer 5

Bongela - sticky, clear
Double base - sticky, thick and white
E45 - thick, creamiest, most consistent, white, soft -better absorption

Question 6

Which excipient in the double base gel is responsible for making this product a gel?

Answer 6

Carbomer - polymer matrix that swells when it comes into contact with water forming a gel matrix

Question 7

What is sorbitan laurate and why is it used in doublebase gel?

Answer 7

It is a surfactant - also acts as an emulsifying agent - increases penetration through of drug through skin

Question 8

What is the function of glycerol in the gel and why is it important in the formulation?

Answer 8

Humectant - reduces the loss of water from gel

Emollient properties - greasy and oily