Semester 3: Equations

Question 1

What is the Henderson Hasselbalch Equation?

Answer 1

Question 2

What is the Formula for Bioavailability(F)?

Answer 2

AUC= Area Under the Curve

F= Bioavailability

Question 3

What is the Formula for Volume of Distribution of a Drug?

Answer 3

Vd= Volume of Distribution

F= Drug Bioavailability

Cp0= Plasma Drug Concentration (mg/liter) at zero time

D= Dose

Question 4

What equation would you use to plan a Dose Regimens?

Answer 4

D= Dose

Vd= Volume of Distribution

C0= Drug Concentration

Question 5

What is the formula for Total Body Clearance?

Answer 5

CLt= Total Clearance

CLh= Hepatic Clearance

CLr= Renal Clearance

CLo= Clearance of other Organs

Question 6

What is the Formula for Renal Clearance of a Drug?

Answer 6

F= Urine Flow Rate

Ud= Urine concentration of the drug

Pd= Plasma concentration of the drug

Question 7

What is the formula for Half Life of a Drug?

Answer 7

t1/2= Half Life

Vd= Volume of Distribution

CL= Clearance

Question 8

What is the Formula for Steady State Infusion?

Answer 8

D= The Administered Dose

T= Infusion Time

Css= Plasma Concentration at the Steady State

CL= The Total Clearance