SELENIUM

Question 1

Least abundant however the most toxic of all the essential elements
Ultra-trace element

Answer 1

SELENIUM

Question 2

Functions in human body of Selenium

Answer 2

Selenium is incorporated in the enzyme Glutathione peroxidase (GTH-Px), that plays
important role in normal immune system function, also plays a crucial role in the control of oxygen metabolism.

Question 3

Selenium deficiency occurs due to:

Answer 3

Hemolytic anemia • Clansman’s thrombasthenia (platelet disorder) • Carcinoma • Gastrointestinal cancer • Malnutrition

Question 4

Increased Selenium may occur due to:

Answer 4

Reticuloendothelial neoplasia • Poisoning (toxicity)

Question 5

Laboratory determination of Selenium:

Answer 5

fasting whole blood, serum or plasma sample……in metal free container! • 24hr urine sample…..in metal free container! • Blood or urine measurement can provide good indication of body Selenium levels • Plasma or serum is preferred over whole blood due to sensitivity of determination • Selenium may be determined in hair sample to access degree of deficiency

Question 6

Methods of determination: Selenium

Answer 6

1.Flameless atomic absorption spectrophotometry 2.Spectrofluorometry 3.Neutron activation