Selenium

Question 1

What happens to selenoprotein P at the cell

Answer 1

Selenoprotein P is taken up by endocytosis and the protein is degraded to release selenide

Question 2

•High selenium concentrations are found in:

6 body parts

Answer 2

Thyroid gland, kidneys, liver, heart, pancreas, muscle

Question 3

Where can selenium also be found: 4 body parts

Answer 3

Also found in lungs, brain, bones, red blood cells

Question 4

Main transport for selenium

Answer 4

Selenoprotein P

Question 5

Selenocysteine is a key AA in the synthesis of

Answer 5

Selenoprotein P

Question 6

Selenophosphate can be made from all other forms of selenium by

Answer 6

selenophosphate synthetase II

Question 7

What is metabolite of Reduction of selenate, selenite

Answer 7

Selenide

Question 8

•Selenophosphate and serine are used to synthesize

Answer 8

selenocysteine

Question 9

Only endogenously made selenocysteine can be used as a cofactor for

Answer 9

Se-dependent enzymes (as part of tRNA during protein synthesis)

Question 10

1-4 selenocysteines are incorporated into the

Answer 10

protein primary structure during protein synthesis

Question 11

•Plasma selenium deficiency concentrations:

Answer 11

Less than 70 ng/mL

Question 12

•Optimal levels for selenium concentrations

Answer 12

80-90 ng/mL

Question 13

What can also be measure for selenium status

Answer 13

Selenoprotein P and GPX3 in plasma can also be measured

Question 14

Whole blood glutathione peroxidase activity reflects longer term status of

Answer 14

Selenium

Question 15

•Urinary selenium may also reflect status, especially?

Answer 15

Toxicity

Question 16

Superoxide dismutase is more much susceptible to what deficiency intracellularly

Answer 16

Copper

Question 17

–Mitochondrial form of SOD requires

Answer 17

Manganese

Question 18

–Mn deficiency decreases

Answer 18

SOD activity

Question 19

Receptors for selenoprotein P are found on cell membranes of

Answer 19

body tissues