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Cholinergic Drugs SM > Selective Inhibitors of Acetylcholineterase > Flashcards

Selective Inhibitors of Acetylcholineterase Flashcards

1
Q

Donepezil
MOA

A

reversible inhibition of acetylcholinesterase. Enhances cholinergic transmission in the cerebral cortex and hippocampus

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2
Q

Donepezil
Abs/Distrb/Elim

A

Orally active
Long half-life of 70 hr

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3
Q

Donepezil
Clinical Use

A

Mild to moderate Alzheimer’s disease, providing limited relief from the symptoms but having no effect on the progression of the disease

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4
Q

Donepezil
Adverse effects

A

Nausea, diarrhea, vomiting, bradycardia, increased gastric secretion
Anorexia with weight loss
Insomnia

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Cholinergic Drugs SM (7 decks)

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