Muscarinic Receptor Agonist

Question 1

Pilocarpine
MOA

Answer 1

Parasympathomimetic actions: contracts smooth muscle (e.g. gut, bladder, pupil);
decreases rate and force of heart beat;
glandular secretion (e.g. salivary, sweat, gastric acid);
inhibits neurotransmitter
release.

Question 2

Pilocarpine
Abs/Distrb/Elim

Answer 2

For glaucoma pilocarpine is given as eye drops and actions last for a day. A slow delivery system
placed under the eyelid acts for several days.

Question 3

Pilocarpine
Clinical use

Answer 3

Glaucoma (narrow and wide angle).

Question 4

Pilocarpine
Adverse effects

Answer 4

Blurred vision (contraction of ciliary muscle). Otherwise few unwanted effects because of very
limited systemic absorption of topically applied drug