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Cholinergic Drugs SM > Irreversible Cholinesterase Inhibitors > Flashcards

Irreversible Cholinesterase Inhibitors Flashcards

1
Q

Dyflos / Sarin
MOA

A

Irreversible inhibition of acetylcholinesterase increases the actions of released ACh at cholinergic nerve endings. It binds to the enzyme esteratic site causing irreversible phosphorylation

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2
Q

Dyflos / Sarin
Abs/Distrb/Elim

A

Most are readily absorbed through the skin, gut, and lungs.
Long acting

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3
Q

Dyflos / Sarin
Clinical use

A

Glaucoma

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4
Q

Dyflos / Sarin
Adverse effects

A
  • May exacerbate asthma
  • Persistent potentiation of ACh action can lead to seizures
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Cholinergic Drugs SM (7 decks)

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